Does Probiotic Consumption Enhance Wound Healing? A Systematic Review

Overview

Journal Nutrients

Date 2022 Jan 11

PMID 35010987

Authors

Camille Togo

Ana Paula Zidorio

Vivian Goncalves

Patricia Botelho

Kenia de Carvalho

Eliane Dutra

Affiliations

Soon will be listed here.

Abstract

The use of probiotics is one of the emerging lines of treatment for wound healing. This systematic review aimed to summarize currently available evidence on the effect of oral or enteral probiotic therapy on skin or oral mucosal wound healing in humans. To verify the developments in this field and the level of available scientific evidence, we applied a broad search strategy with no restrictions on wound type, target population, probiotic strain, or intervention protocol used. This review included seven studies involving 348 individuals. Four studies reported positive outcomes for healing improvement after probiotic therapy, and none of the studies reported adverse effects or a marked increase in wound healing time. The positive or neutral results observed do not generate strong evidence regarding the effectiveness of probiotics for wound healing. However, they suggest a promising field for future clinical research where the probiotic strains used, type of wounds, and target population are controlled for.

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References

Yu Y, Dunaway S, Champer J, Kim J, Alikhan A . Changing our microbiome: probiotics in dermatology. Br J Dermatol. 2019; 182(1):39-46. DOI: 10.1111/bjd.18088. View

Hempel S, Newberry S, Ruelaz A, Wang Z, Miles J, Suttorp M . Safety of probiotics used to reduce risk and prevent or treat disease. Evid Rep Technol Assess (Full Rep). 2012; (200):1-645. PMC: 4780970. View

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100. PMC: 2707010. DOI: 10.1371/journal.pmed.1000100. View

Dong H, Rowland I, Yaqoob P . Comparative effects of six probiotic strains on immune function in vitro. Br J Nutr. 2011; 108(3):459-70. DOI: 10.1017/S0007114511005824. View

Broughton 2nd G, Janis J, Attinger C . Wound healing: an overview. Plast Reconstr Surg. 2006; 117(7 Suppl):1e-S-32e-S. DOI: 10.1097/01.prs.0000222562.60260.f9. View

Alvarez-Arrano V, Martin-Pelaez S . Effects of Probiotics and Synbiotics on Weight Loss in Subjects with Overweight or Obesity: A Systematic Review. Nutrients. 2021; 13(10). PMC: 8540110. DOI: 10.3390/nu13103627. View

Gosain A, DiPietro L . Aging and wound healing. World J Surg. 2004; 28(3):321-6. DOI: 10.1007/s00268-003-7397-6. View

Walivaara D, Sjogren I, Gerasimcik N, Yucel-Lindberg T, Twetman S, Abrahamsson P . Effects of -containing lozenges on healing after surgical removal of mandibular third molars: a randomised controlled trial. Benef Microbes. 2019; 10(6):653-659. DOI: 10.3920/BM2018.0168. View

Poutahidis T, Kearney S, Levkovich T, Qi P, Varian B, Lakritz J . Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS One. 2013; 8(10):e78898. PMC: 3813596. DOI: 10.1371/journal.pone.0078898. View

10.

Salminen S, Collado M, Isolauri E, Gueimonde M . Microbial-host interactions: selecting the right probiotics and prebiotics for infants. Nestle Nutr Workshop Ser Pediatr Program. 2009; 64:201-13. DOI: 10.1159/000235792. View

11.

Kekkonen R, Kajasto E, Miettinen M, Veckman V, Korpela R, Julkunen I . Probiotic Leuconostoc mesenteroides ssp. cremoris and Streptococcus thermophilus induce IL-12 and IFN-gamma production. World J Gastroenterol. 2008; 14(8):1192-203. PMC: 2690666. DOI: 10.3748/wjg.14.1192. View

12.

Quain A, Khardori N . Nutrition in Wound Care Management: A Comprehensive Overview. Wounds. 2016; 27(12):327-35. View

13.

Hart A, Lammers K, Brigidi P, Vitali B, Rizzello F, Gionchetti P . Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut. 2004; 53(11):1602-9. PMC: 1774301. DOI: 10.1136/gut.2003.037325. View

14.

Esposito C, Roberti A, Turra F, Cerulo M, Severino G, Settimi A . Frequency of Antibiotic-Associated Diarrhea and Related Complications in Pediatric Patients Who Underwent Hypospadias Repair: a Comparative Study Using Probiotics vs Placebo. Probiotics Antimicrob Proteins. 2017; 10(2):323-328. DOI: 10.1007/s12602-017-9324-4. View

15.

Lukic J, Chen V, Strahinic I, Begovic J, Lev-Tov H, Davis S . Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound Repair Regen. 2018; 25(6):912-922. PMC: 5854537. DOI: 10.1111/wrr.12607. View

16.

Patel S, Srivastava S, Singh M, Singh D . Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing. Biomed Pharmacother. 2019; 112:108615. DOI: 10.1016/j.biopha.2019.108615. View

17.

Borchers A, Selmi C, Meyers F, Keen C, Gershwin M . Probiotics and immunity. J Gastroenterol. 2009; 44(1):26-46. DOI: 10.1007/s00535-008-2296-0. View

18.

Hsu C, Wang L . Emerging treatment of atopic dermatitis. Clin Rev Allergy Immunol. 2007; 33(3):199-203. DOI: 10.1007/s12016-007-0043-6. View

19.

McGowan J, Sampson M, Salzwedel D, Cogo E, Foerster V, Lefebvre C . PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement. J Clin Epidemiol. 2016; 75:40-6. DOI: 10.1016/j.jclinepi.2016.01.021. View

20.

Spanos K, Saleptsis V, Athanasoulas A, Karathanos C, Bargiota A, Chan P . Factors Associated With Ulcer Healing and Quality of Life in Patients With Diabetic Foot Ulcer. Angiology. 2016; 68(3):242-250. DOI: 10.1177/0003319716651166. View