The Exposome and Immune Health in Times of the COVID-19 Pandemic

Overview

Journal Nutrients

Date 2022 Jan 11

PMID 35010900

Authors

Javier S Morales

Pedro L Valenzuela

Adrian Castillo-Garcia

Javier Butragueno

David Jimenez-Pavon

Pedro Carrera-Bastos

Alejandro Lucia

Affiliations

Soon will be listed here.

Abstract

Growing evidence supports the importance of lifestyle and environmental exposures-collectively referred to as the 'exposome'-for ensuring immune health. In this narrative review, we summarize and discuss the effects of the different exposome components (physical activity, body weight management, diet, sun exposure, stress, sleep and circadian rhythms, pollution, smoking, and gut microbiome) on immune function and inflammation, particularly in the context of the current coronavirus disease 2019 (COVID-19) pandemic. We highlight the potential role of 'exposome improvements' in the prevention-or amelioration, once established-of this disease as well as their effect on the response to vaccination. In light of the existing evidence, the promotion of a healthy exposome should be a cornerstone in the prevention and management of the COVID-19 pandemic and other eventual pandemics.

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