Genetic Background of Fetal Growth Restriction

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Jan 11

PMID 35008459

Authors

Beata Anna Nowakowska

Katarzyna Pankiewicz

Urszula Nowacka

Magdalena Niemiec

Szymon Kozlowski

Tadeusz Issat

Affiliations

Soon will be listed here.

Abstract

Fetal growth restriction (FGR) is one of the most formidable challenges in present-day antenatal care. Pathological fetal growth is a well-known factor of not only in utero demise in the third trimester, but also postnatal morbidity and unfavorable developmental outcomes, including long-term sequalae such as metabolic diseases, diabetic mellitus or hypertension. In this review, the authors present the current state of knowledge about the genetic disturbances responsible for FGR diagnosis, divided into fetal, placental and maternal causes (including preeclampsia), as well as their impact on prenatal diagnostics, with particular attention on chromosomal microarray (CMA) and noninvasive prenatal testing technique (NIPT).

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References

An G, Lin Y, Xu L, Huang H, Liu S, Yu Y . Application of chromosomal microarray to investigate genetic causes of isolated fetal growth restriction. Mol Cytogenet. 2018; 11:33. PMC: 5987400. DOI: 10.1186/s13039-018-0382-4. View

Del Gobbo G, Yuan V, Robinson W . Confined placental mosaicism involving multiple de novo copy number variants associated with fetal growth restriction: A case report. Am J Med Genet A. 2021; 185(6):1908-1912. PMC: 8251599. DOI: 10.1002/ajmg.a.62183. View

Lees C, Stampalija T, Baschat A, da Silva Costa F, Ferrazzi E, Figueras F . ISUOG Practice Guidelines: diagnosis and management of small-for-gestational-age fetus and fetal growth restriction. Ultrasound Obstet Gynecol. 2020; 56(2):298-312. DOI: 10.1002/uog.22134. View

Tzadikevitch Geffen K, Singer A, Maya I, Ben-Shachar S, Sagi-Dain L, Daum H . The Yield of Chromosomal Microarray in Pregnancies Complicated with Fetal Growth Restriction Can Be Predicted According to Clinical Parameters. Fetal Diagn Ther. 2020; 48(2):140-148. DOI: 10.1159/000511475. View

Miura K, Yoshiura K, Miura S, Kondoh T, Harada N, Yamasaki K . Clinical outcome of infants with confined placental mosaicism and intrauterine growth restriction of unknown cause. Am J Med Genet A. 2006; 140A(17):1827-33. DOI: 10.1002/ajmg.a.31389. View

Nasri F, Zare M, Hesampour F, Ahmadi M, Ali-Hassanzadeh M, Mostafaei S . Are genetic variations in IL-1β and IL-6 cytokines associated with the risk of pre-eclampsia? Evidence from a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2021; 35(25):6600-6609. DOI: 10.1080/14767058.2021.1918092. View

Chelbi S, Wilson M, Veillard A, Ingles S, Zhang J, Mondon F . Genetic and epigenetic mechanisms collaborate to control SERPINA3 expression and its association with placental diseases. Hum Mol Genet. 2012; 21(9):1968-78. DOI: 10.1093/hmg/dds006. View

Hellstrom A, Ley D, Hansen-Pupp I, Hallberg B, Lofqvist C, Van Marter L . Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016; 105(6):576-86. PMC: 5069563. DOI: 10.1111/apa.13350. View

Golovchenko O, Abramova M, Ponomarenko I, Reshetnikov E, Aristova I, Polonikov A . Functionally significant polymorphisms of ESR1and PGR and risk of intrauterine growth restriction in population of Central Russia. Eur J Obstet Gynecol Reprod Biol. 2020; 253:52-57. DOI: 10.1016/j.ejogrb.2020.07.045. View

10.

Benny P, Alakwaa F, Schlueter R, Lassiter C, Garmire L . A review of omics approaches to study preeclampsia. Placenta. 2020; 92:17-27. PMC: 7306500. DOI: 10.1016/j.placenta.2020.01.008. View

11.

Nowacka U, Papastefanou I, Bouariu A, Syngelaki A, Akolekar R, Nicolaides K . Second-trimester contingent screening for small-for-gestational-age neonate. Ultrasound Obstet Gynecol. 2021; 59(2):177-184. DOI: 10.1002/uog.23730. View

12.

Liu J, Song G, Zhao G, Meng T . Gene polymorphism associated with TGF-β1 and susceptibility to preeclampsia: A meta-analysis and trial sequential analysis. J Obstet Gynaecol Res. 2021; 47(6):2031-2041. DOI: 10.1111/jog.14751. View

13.

Murthi P . Review: placental homeobox genes and their role in regulating human fetal growth. Placenta. 2013; 35 Suppl:S46-50. DOI: 10.1016/j.placenta.2013.11.006. View

14.

Thaete L, Dewey E, Neerhof M . Endothelin and the regulation of uterine and placental perfusion in hypoxia-induced fetal growth restriction. J Soc Gynecol Investig. 2004; 11(1):16-21. DOI: 10.1016/j.jsgi.2003.07.001. View

15.

Hammami A, Mazer Zumaeta A, Syngelaki A, Akolekar R, Nicolaides K . Ultrasonographic estimation of fetal weight: development of new model and assessment of performance of previous models. Ultrasound Obstet Gynecol. 2018; 52(1):35-43. DOI: 10.1002/uog.19066. View

16.

Meler E, Sisterna S, Borrell A . Genetic syndromes associated with isolated fetal growth restriction. Prenat Diagn. 2020; 40(4):432-446. DOI: 10.1002/pd.5635. View

17.

Nardozza L, Caetano A, Zamarian A, Mazzola J, Silva C, Marcal V . Fetal growth restriction: current knowledge. Arch Gynecol Obstet. 2017; 295(5):1061-1077. DOI: 10.1007/s00404-017-4341-9. View

18.

Zhao L, Bracken M, DeWan A, Chen S . Association between the SERPINE1 (PAI-1) 4G/5G insertion/deletion promoter polymorphism (rs1799889) and pre-eclampsia: a systematic review and meta-analysis. Mol Hum Reprod. 2012; 19(3):136-43. DOI: 10.1093/molehr/gas056. View

19.

Sljivancanin Jakovljevic T, Kontic-Vucinic O, Nikolic N, Carkic J, Stamenkovic J, Soldatovic I . Association Between Endothelial Nitric Oxide Synthase (eNOS) -786 T/C and 27-bp VNTR 4b/a Polymorphisms and Preeclampsia Development. Reprod Sci. 2021; 28(12):3529-3539. DOI: 10.1007/s43032-021-00632-0. View

20.

Pankiewicz K, Fijalkowska A, Issat T, Maciejewski T . Insight into the Key Points of Preeclampsia Pathophysiology: Uterine Artery Remodeling and the Role of MicroRNAs. Int J Mol Sci. 2021; 22(6). PMC: 8003365. DOI: 10.3390/ijms22063132. View