Amphiphilic DTPA Multimer Assembled on Icosahedral -Borane Motif As High-Performance MRI Blood Pool Contrast Agent

Overview

Journal ACS Appl Bio Mater

Specialties Biomedical Engineering
Biotechnology

Date 2022 Jan 10

PMID 35006969

Authors

Lalit N Goswami

Shatadru Chakravarty

Quan-Yu Cai

Erik M Shapiro

M Frederick Hawthorne

Lixin Ma

Affiliations

Soon will be listed here.

Abstract

A multimeric MRI blood pool contrast agent based on the -borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized -borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement and .

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