Daily Activity Relates to Not Only Femoral Bone Mineral Density, but Also Hip Structural Analysis Parameters: A Cross-sectional Observational Study

Overview

Journal Osteoporos Sarcopenia

Date 2022 Jan 10

PMID 35005248

Authors

Norifumi Fujii

Nobukazu Okimoto

Manabu Tsukamoto

Norimitsu Fujii

Kei Asano

Yoshiaki Ikejiri

Toru Yoshioka

Takafumi Tajima

Yoshiaki Yamanaka

Yukichi Zenke

Makoto Kawasaki

Junya Ozawa

Takuya Umehara

Shogo Takano

Hideaki Murata

Nobuhiro Kito

Affiliations

Soon will be listed here.

Abstract

Objectives: Physical activity to maintain bone mass and strength is important for hip fracture prevention. We aim to investigate the relationship between physical performance/activity status and bone mineral density (BMD)/hip structural analysis (HSA) parameters among postmenopausal women in Japan.

Methods: Sixty-two postmenopausal women diagnosed with osteoporosis (mean age: 72.61 ± 7.43 years) were enrolled in this cross-sectional observational study. They were evaluated for BMD and HSA in the proximal femur by dual-energy X-ray absorptiometry and underwent several physical performance tests, the Geriatric Locomotive Function Scale of 25 questions (GLFS-25). Principal component analysis (PCA) was used to summarize data on the BMD/HSA parameters. Partial correlation analysis, multiple regression analysis, and structural equation modeling (SEM) were performed to investigate the relationship between physical performance/activity status and BMD/HSA parameters of the proximal femur.

Results: In a partial correlation analysis adjusted for age and body mass index (BMI), GLFS-25 scores were correlated with HSA parameter (|r| = 0.260-0.396, P < 0.05). Principal component 1 (PC1) calculated by PCA was interpreted as more reflective of bone strength based on the value of BMD/HSA parameters. The SEM results showed that the model created by the 3 questions (Q13, brisk walking; Q15, keep walking without rest; Q20, load-bearing tasks and housework) of the GLFS-25 had the best fit and was associated with the PC1 score (β = -0.444, P = 0.001).

Conclusions: The GLFS-25 score was associated with the BMD/HSA parameter, which may reflect the bone strength of the proximal femur as calculated by PCA.

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