Multidisciplinary Treatment of Advanced or Recurrent Solid Pseudopapillary Neoplasm of the Pancreas: Three Case Reports

Overview

Journal Surg Case Rep

Specialty General Surgery

Date 2022 Jan 10

PMID 35001187

Authors

Kiyonori Tanoue

Yuko Mataki

Hiroshi Kurahara

Tetsuya Idichi

Yota Kawasaki

Yoichi Yamasaki

Yoshiaki Kita

Yuto Hozaka

Hideyuki Oi

Akihiro Nakajo

Takaaki Arigami

Kosei Maemura

Takao Ohtsuka

Affiliations

Soon will be listed here.

Abstract

Background: Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor that predominantly affects young females. Prognosis is excellent; however, 10-15% of patients show metastasis at the time of surgery or develop tumor recurrence after pancreatectomy.

Case Presentation: We reviewed the clinical course of three patients with advanced or recurrent SPN and subsequently underwent multidisciplinary treatment at our institution between 2002 and 2019. The primary tumor was resected in all three patients, and metastases were also resected if indicated. Intensive combined therapy, including re-resection, chemotherapy, ablation, arterial chemoembolization, and radiation therapy, allowed all patients to survive for a long time. The literature review showed that resection seems to be more effective than other treatments for metastatic SPN.

Conclusions: Multidisciplinary treatment, including resection, may improve the prognosis of patients with SPN with recurrence or metastasis.

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