Small, but Powerful and Attractive: F in Biomolecular NMR

Overview

Journal Structure

Publisher Cell Press

Specialties Biochemistry
Biotechnology
Cell Biology
Molecular Biology

Date 2022 Jan 7

PMID 34995480

Citations 31

Authors

Angela M Gronenborn

Affiliations

Soon will be listed here.

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for probing structure, dynamics, folding, and interactions at atomic resolution. While naturally occurring magnetically active isotopes, such as H, C, or N, are most commonly used in biomolecular NMR, with N and C isotopic labeling routinely employed at the present time, F is a very attractive and sensitive alternative nucleus, which offers rich information on biomolecules in solution and in the solid state. This perspective summarizes the unique benefits of solution and solid-state F NMR spectroscopy for the study of biological systems. Particular focus is on the most recent studies and on future unique and important potential applications of fluorine NMR methodology.

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