Microbiome-based Therapeutics

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2022 Jan 7

PMID 34992261

Citations 133

Authors

Matthew T Sorbara

Eric G Pamer

Affiliations

Soon will be listed here.

Abstract

Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing susceptibility to infection and enhancing resistance to a range of diseases. In this Review, we discuss our increasing understanding of the impact of the microbiome on the mammalian host and recent efforts to culture and characterize intestinal symbiotic microorganisms that produce or modify metabolites that impact disease pathology. Manipulation of the intestinal microbiome has great potential to reduce the incidence and/or severity of a wide range of human conditions and diseases, and the biomedical research community now faces the challenge of translating our understanding of the microbiome into beneficial medical therapies. Our increasing understanding of symbiotic microbial species and the application of ecological principles and machine learning are providing exciting opportunities for microbiome-based therapeutics to progress from faecal microbiota transplantation to the administration of precisely defined and clinically validated symbiotic microbial consortia that optimize disease resistance.

Citing Articles

Faecal microbiota transplantation for eradicating Helicobacter pylori infection: clinical practice and theoretical postulation.

Ye Z, Eslick G, Huang S, He X eGastroenterology. 2025; 2(4):e100099.

PMID: 39944265 PMC: 11770466. DOI: 10.1136/egastro-2024-100099.

Lifestyle Factors and the Microbiome in Urolithiasis: A Narrative Review.

Koudonas A, Tsiakaras S, Tzikoulis V, Papaioannou M, de la Rosette J, Anastasiadis A Nutrients. 2025; 17(3).

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Pneumonia Severity Is Associated with Taxonomic Shifts in the Respiratory Microbiota.

Del Prete V, Piazzesi A, Scanu M, Toto F, Pane S, Berrilli F Pathogens. 2025; 14(1).

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Is Intestinal Microbiota Fully Restored After Chickens Have Recovered from Coccidiosis?.

Guo J, Zhao Z, Broadwater C, Tobin I, Liu J, Whitmore M Pathogens. 2025; 14(1.

PMID: 39861042 PMC: 11768824. DOI: 10.3390/pathogens14010081.

Microbes Saving Lives and Reducing Suffering.

Timmis K, Karahan Z, Ramos J, Koren O, Perez-Cobas A, Steward K Microb Biotechnol. 2025; 18(1):e70068.

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