Better and Greener: Sustainable Pharmaceutical Manufacturing Technologies for Highly Bioavailable Solid Dosage Forms

Overview

Journal Drug Deliv Transl Res

Publisher Springer

Specialty Pharmacology

Date 2022 Jan 6

PMID 34988827

Citations 3

Authors

Serena Bertoni

Dritan Hasa

Beatrice Albertini

Beatrice Perissutti

Mario Grassi

Dario Voinovich

Nadia Passerini

Affiliations

Soon will be listed here.

Abstract

In the last decades, Green Chemistry has been gaining widespread attention within the pharmaceutical field. It is thus very important to bring more sustainable approaches into the design and manufacture of effective oral drug delivery systems. This review focuses on spray congealing and mechanochemical activation, two technologies endorsing different principles of green chemistry, and at the same time, addressing some of the challenges related to the transformation of poorly water-soluble drugs in highly bioavailable solid dosage forms. We therefore present an overview of the basic principles, equipment, and application of these particle-engineering technologies, with specific attention to case studies carried out by the groups working in Italian Universities.

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