Lipid Droplet-a New Target in Ischemic Heart Disease

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2022 Jan 5

PMID 34984637

Citations 2

Authors

Xiaoying Guo

Qi Shi

Wanqin Zhang

Zhongwen Qi

Hao Lv

Fujing Man

YingYu Xie

Yaping Zhu

Junping Zhang

Affiliations

Soon will be listed here.

Abstract

Lipid droplet (LD) is a kind of subcellular organelle, which originates from the endoplasmic reticulum (ER). LDs can move flexibly between other organelles and store energy in the cells. In recent years, LDs and lipid droplet-associated proteins have attracted added attention at home and abroad, especially in cardiovascular diseases. Cardiovascular diseases, especially ischemic heart disease (IHD), have always been the focus of attention because of their high morbidity and mortality. Atherosclerosis and myocardial remodeling are two important pathologic processes of IHD, and LDs and other organelles are involved in the development of the disease. The interaction between LDs and ER is involved in the formation of foam cells in atherosclerosis. And LDs, mitochondria, and lysosomes also affect the remodeling of cardiomyocytes by affecting ROS production and regulating PI3K/AKT pathways. In this article, we will review the role of LDs in IHD.

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References

van Meer G . Cellular lipidomics. EMBO J. 2005; 24(18):3159-65. PMC: 1224688. DOI: 10.1038/sj.emboj.7600798. View

Ayyappan J, Paul A, Goo Y . Lipid droplet-associated proteins in atherosclerosis (Review). Mol Med Rep. 2016; 13(6):4527-34. PMC: 4878557. DOI: 10.3892/mmr.2016.5099. View

Saliba A, Vonkova I, Gavin A . The systematic analysis of protein-lipid interactions comes of age. Nat Rev Mol Cell Biol. 2015; 16(12):753-61. DOI: 10.1038/nrm4080. View

Stanley W, Recchia F, Lopaschuk G . Myocardial substrate metabolism in the normal and failing heart. Physiol Rev. 2005; 85(3):1093-129. DOI: 10.1152/physrev.00006.2004. View

Lopaschuk G, Belke D, Gamble J, Itoi T, Schonekess B . Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta. 1994; 1213(3):263-76. DOI: 10.1016/0005-2760(94)00082-4. View

Gidda S, Park S, Pyc M, Yurchenko O, Cai Y, Wu P . Lipid Droplet-Associated Proteins (LDAPs) Are Required for the Dynamic Regulation of Neutral Lipid Compartmentation in Plant Cells. Plant Physiol. 2016; 170(4):2052-71. PMC: 4825156. DOI: 10.1104/pp.15.01977. View

Xu W, Wu L, Yu M, Chen F, Arshad M, Xia X . Differential Roles of Cell Death-inducing DNA Fragmentation Factor-α-like Effector (CIDE) Proteins in Promoting Lipid Droplet Fusion and Growth in Subpopulations of Hepatocytes. J Biol Chem. 2016; 291(9):4282-93. PMC: 4813457. DOI: 10.1074/jbc.M115.701094. View

Karanasios E, Han G, Xu Z, Carman G, Siniossoglou S . A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphatase. Proc Natl Acad Sci U S A. 2010; 107(41):17539-44. PMC: 2955120. DOI: 10.1073/pnas.1007974107. View

Adeyo O, Horn P, Lee S, Binns D, Chandrahas A, Chapman K . The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets. J Cell Biol. 2011; 192(6):1043-55. PMC: 3063132. DOI: 10.1083/jcb.201010111. View

10.

Szymanski K, Binns D, Bartz R, Grishin N, Li W, Agarwal A . The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology. Proc Natl Acad Sci U S A. 2007; 104(52):20890-5. PMC: 2409237. DOI: 10.1073/pnas.0704154104. View

11.

Gross D, Zhan C, Silver D . Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation. Proc Natl Acad Sci U S A. 2011; 108(49):19581-6. PMC: 3241795. DOI: 10.1073/pnas.1110817108. View

12.

Jackson C . Lipid droplet biogenesis. Curr Opin Cell Biol. 2019; 59:88-96. DOI: 10.1016/j.ceb.2019.03.018. View

13.

Talukder M, Sim M, ORahilly S, Edwardson J, Rochford J . Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis. Mol Metab. 2015; 4(3):199-209. PMC: 4338318. DOI: 10.1016/j.molmet.2014.12.013. View

14.

Hayes M, Choudhary V, Ojha N, Shin J, Han G, Carman G . Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes. Microb Cell. 2018; 5(2):88-103. PMC: 5798408. DOI: 10.15698/mic2018.02.614. View

15.

Choudhary V, Ojha N, Golden A, Prinz W . A conserved family of proteins facilitates nascent lipid droplet budding from the ER. J Cell Biol. 2015; 211(2):261-71. PMC: 4621845. DOI: 10.1083/jcb.201505067. View

16.

Joshi A, Nebenfuehr B, Choudhary V, Satpute-Krishnan P, Levine T, Golden A . Lipid droplet and peroxisome biogenesis occur at the same ER subdomains. Nat Commun. 2018; 9(1):2940. PMC: 6063926. DOI: 10.1038/s41467-018-05277-3. View

17.

Wang S, Idrissi F, Hermansson M, Grippa A, Ejsing C, Carvalho P . Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum. Nat Commun. 2018; 9(1):2939. PMC: 6063905. DOI: 10.1038/s41467-018-05278-2. View

18.

Gao G, Chen F, Zhou L, Su L, Xu D, Xu L . Control of lipid droplet fusion and growth by CIDE family proteins. Biochim Biophys Acta Mol Cell Biol Lipids. 2017; 1862(10 Pt B):1197-1204. DOI: 10.1016/j.bbalip.2017.06.009. View

19.

Farese Jr R, Walther T . Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 2009; 139(5):855-60. PMC: 3097139. DOI: 10.1016/j.cell.2009.11.005. View

20.

Dupont N, Chauhan S, Arko-Mensah J, Castillo E, Masedunskas A, Weigert R . Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis. Curr Biol. 2014; 24(6):609-20. PMC: 4016984. DOI: 10.1016/j.cub.2014.02.008. View