Comparative Studies on the Gastrointestinal Lesions Caused by Several Nonsteroidal Anti-inflammatory Agents in Rats

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1987 Jun 1

PMID 3498312

Citations 2

Authors

T Suwa

H Urano

Y Kohno

A Suzuki

T Amano

Affiliations

Soon will be listed here.

Abstract

The gastrointestinal toxicity of a single oral administration of five nonsteroidal anti-inflammatory agents (NSAIDs) to rats was compared, by a method using 51Cr-labeled red blood cells (RBC), and by macroscopic and microscopic examination. From the profile of gastrointestinal bleeding, the NSAIDs could be divided into a group consisting of aspirin (ASA), oxaprozin (OXP) and 2-[4-(3-methyl-2-butenyl)phenyl]propionic acid (TA), which caused only a transient increase in fecal blood loss based on a gastric lesion, and another group including indomethacin (IM) and ibuprofen (IP), which produced a biphasic increase in the blood loss. The initial phase was caused not only by a gastric lesion but also an intestinal lesion, and the secondary phase originated only in the intestinal lesion. The order of potency causing blood loss was IM much greater than IP greater than ASA much greater than TA greater than OXP. The safety ratio of OXP and TA was shown to be more favorable than that of the other three drugs.

Citing Articles

Recombinant Human Epidermal Growth Factor Alleviates Gastric Antral Ulcer Induced by Naproxen: A Non-steroidal Anti Inflammatory Drug.

Chairmandurai A, Kanappa S, Vadrevu K, Putcha U, Venkatesan V Gastroenterology Res. 2016; 3(3):125-133.

PMID: 27942290 PMC: 5139766. DOI: 10.4021/gr2010.05.199w.

Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat.

Calhoun W, Gilman S, Datko L, Copenhaver T, Carlson R Agents Actions. 1992; 36(1-2):99-106.

PMID: 1414694 DOI: 10.1007/BF01991236.

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