Biochanin A Sensitizes Glioblastoma to Temozolomide by Inhibiting Autophagy

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2022 Jan 4

PMID 34981417

Citations 9

Authors

Qiang Dong

Degui Wang

Lanlan Li

Jie Wang

Qiao Li

Lei Duan

Hang Yin

Xiaoqing Wang

Yang Liu

Guoqiang Yuan

Yawen Pan

Affiliations

Soon will be listed here.

Abstract

Resistance to temozolomide (TMZ) chemotherapy is the main reason for treatment failure in patients with glioblastoma (GBM). In the present study, we investigated biochanin A (BCA) a potent sensitizer of TMZ in GBM. We observed that BCA significantly enhanced cell sensitivity to TMZ in vitro and in vivo. Mechanistically, the specific chemosensitizing effect of BCA is mediated by autophagy inhibition. Moreover, by performing a molecular docking analysis, we demonstrated that BCA interacts with AMPK residues and impairs autophagy by regulating the AMPK/ULK1 pathway. These results suggest that BCA is a potential therapeutic agent that sensitizes GBM to TMZ and provide new insight into its therapeutic potential in chemoresistant GBM.

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