» Articles » PMID: 34977019

Regeneration in Echinoderms: Molecular Advancements

Overview
Specialty Cell Biology
Date 2022 Jan 3
PMID 34977019
Citations 11
Authors
Affiliations
Soon will be listed here.
Abstract

Which genes and gene signaling pathways mediate regenerative processes? In recent years, multiple studies, using a variety of animal models, have aimed to answer this question. Some answers have been obtained from transcriptomic and genomic studies where possible gene and gene pathway candidates thought to be involved in tissue and organ regeneration have been identified. Several of these studies have been done in echinoderms, an animal group that forms part of the deuterostomes along with vertebrates. Echinoderms, with their outstanding regenerative abilities, can provide important insights into the molecular basis of regeneration. Here we review the available data to determine the genes and signaling pathways that have been proposed to be involved in regenerative processes. Our analyses provide a curated list of genes and gene signaling pathways and match them with the different cellular processes of the regenerative response. In this way, the molecular basis of echinoderm regenerative potential is revealed, and is available for comparisons with other animal taxa.

Citing Articles

Regeneration, Regengrow and Tissue Repair in Animals: Evolution Indicates That No Regeneration Occurs in Terrestrial Environments but Only Recovery Healing.

Alibardi L J Dev Biol. 2025; 13(1.

PMID: 39846631 PMC: 11755470. DOI: 10.3390/jdb13010002.


Research Progress on Starfish Outbreaks and Their Prevention and Utilization: Lessons from Northern China.

Qu L, Sun Y, Zhao C, Elphick M, Wang Q Biology (Basel). 2024; 13(7).

PMID: 39056729 PMC: 11273428. DOI: 10.3390/biology13070537.


The brittle star genome illuminates the genetic basis of animal appendage regeneration.

Parey E, Ortega-Martinez O, Delroisse J, Piovani L, Czarkwiani A, Dylus D Nat Ecol Evol. 2024; 8(8):1505-1521.

PMID: 39030276 PMC: 11310086. DOI: 10.1038/s41559-024-02456-y.


Echinobase: a resource to support the echinoderm research community.

Telmer C, Karimi K, Chess M, Agalakov S, Arshinoff B, Lotay V Genetics. 2024; 227(1).

PMID: 38262680 PMC: 11075573. DOI: 10.1093/genetics/iyae002.


Ethical Considerations for Echinoderms: New Initiatives in Welfare.

Crespi-Abril A, Rubilar T Animals (Basel). 2023; 13(21).

PMID: 37958130 PMC: 10647474. DOI: 10.3390/ani13213377.


References
1.
Vogg M, Galliot B, Tsiairis C . Model systems for regeneration: . Development. 2019; 146(21). DOI: 10.1242/dev.177212. View

2.
Sun L, Yang H, Chen M, Ma D, Lin C . RNA-Seq reveals dynamic changes of gene expression in key stages of intestine regeneration in the sea cucumber Apostichopus japonicus. [corrected]. PLoS One. 2013; 8(8):e69441. PMC: 3735544. DOI: 10.1371/journal.pone.0069441. View

3.
Flowers G, Crews C . Regeneration writ large. Nature. 2018; 554(7690):34-35. DOI: 10.1038/d41586-017-09008-4. View

4.
Cary G, Wolff A, Zueva O, Pattinato J, Hinman V . Analysis of sea star larval regeneration reveals conserved processes of whole-body regeneration across the metazoa. BMC Biol. 2019; 17(1):16. PMC: 6385403. DOI: 10.1186/s12915-019-0633-9. View

5.
Patruno M, Smertenko A, Carnevali M, Bonasoro F, Beesley P, Thorndyke M . Expression of transforming growth factor beta-like molecules in normal and regenerating arms of the crinoid Antedon mediterranea: immunocytochemical and biochemical evidence. Proc Biol Sci. 2002; 269(1502):1741-7. PMC: 1691104. DOI: 10.1098/rspb.2002.2010. View