Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2021 Dec 30

PMID 34967570

Citations 2

Authors

Pranee Sriraj

Thidarut Boonmars

Ratchadawan Aukkanimart

Atchara Artchayasawat

Glenn N Borlace

Panaratana Ratanasuwan

Benjamabhorn Pumhirunroj

Affiliations

Soon will be listed here.

Abstract

Objective: This study therefore aimed at investigating effects of acetaminophen on pathogenesis in hamsters for opisthorchiasis.

Methods: There were 4 groups of hamsters: i) uninfected hamster (N); ii) sole acetaminophen administration (N-Ac); iii) sole O. viverrini infection (OV); and iv) combination of O. viverrini infection and acetaminophen (OV-Ac) on pathology of hamsters for 1 month post infection. For analysis of histopathological changes through hematoxylin and eosin, Sirius red and immunohistostaining for Cytokeratin 19 (CK-19), Proliferating cell nuclear antigen (PCNA) and CA 19-9, serum's hamsters were used detected for liver function tests and tumor-related genes expression.

Results: After 1 month under these treatments, the OV-Ac showed significantly higher CCA risk, including inflammatory cells were aggregations around bile duct, new bile duct and fibrosis in subcapsular hepatic tissues, than other treatments. These pathological parameters were positively correlated with immunohistochemical staining derived from CK-19, PCNA and CA 19-9. In addition, OV-Ac had significantly higher liver function tests (ALT).

Conclusion: Combined intake of liver fluke-contaminated raw fishes and acetaminophen rendered more severity of CCA than sole consumption of the contaminated raw fishes.

Citing Articles

The antioxidant, anti-cholangiocarcinoma, and anti- activities of ethanolic extract from fruit.

Aukkanimart R, Sriraj P, Changthong A, Promsrisuk T J Adv Vet Anim Res. 2024; 11(3):637-647.

PMID: 39605764 PMC: 11590606. DOI: 10.5455/javar.2024.k813.

Opisthorchiasis, Acetaminophen Overdose and Cholangiocarcinoma : Correspondence.

Mungmunpuntipantip R, Wiwanitkit V Asian Pac J Cancer Prev. 2022; 23(1):1.

PMID: 35092365 PMC: 9258678. DOI: 10.31557/APJCP.2022.23.1.1.

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