LINC00839 Knockdown Restrains the Metastatic Behavior of Nasopharyngeal Carcinoma by Sponging MiR-454-3p

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2021 Dec 29

PMID 34965215

Citations 4

Authors

Feng Ying Zhang

Xia Li

Ting Ting Huang

Mei Ling Xiang

Lin Lin Sun

Zhao Lan Sun

Affiliations

Soon will be listed here.

Abstract

Long intergenic non-coding RNA 00839 (LINC00839) has been verified as a pro-metastasis factor in malignancies. However, the significance of LINC00839 in nasopharyngeal carcinoma (NPC) has yet to be illuminated, as well as its underlying mechanism. Here, we disclosed that LINC00839 is highly expressed in NPC. Deletion of LINC00839 suppresses NPC cells rapid growth, invasive capacity and EMT . Besides, LINC00839 is identified as a "sponge" for miR-454-3p, and upregulation of LINC00839 reverses miR-454-3p-mediated inhibition of aggressiveness in NPC cells. Furthermore, the expression of cellular-mesenchymal epithelial transition factor (c-Met), the downstream target of miR-454-3p, is downregulated by LINC00839 knockdown in NPC cells. , LINC00839 knockdown retards the tumor growth of NPC cells in the xenografted mice model. Collectively, attenuation of LINC00839 expression attenuates the aggressive properties of NPC cells via directly sponging the miR-454-3p and regulating c-Met expression.

Citing Articles

The role of long non-coding RNA LINC00839 in oral squamous cell carcinoma based on bioinformatics and experimental research.

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LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia.

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