Uterine Fibroids: Hiding in Plain Sight

Overview

Journal Physiology (Bethesda)

Specialty Physiology

Date 2021 Dec 29

PMID 34964688

Citations 11

Authors

Elizabeth A Stewart

Romana A Nowak

Affiliations

Soon will be listed here.

Abstract

Uterine fibroids (leiomyomas) are present in >75% of women and can cause serious morbidity. They are by far the leading cause of hysterectomy. Fibroids are a complex mixture of cells that include fibroblasts and smooth muscle cells. Rich in extracellular matrix, they typically arise through somatic mutations, most commonly . Their lack of growth inhibition and their ability to have facets of malignancy yet be histologically and biologically benign provide opportunities to explore basic processes. To date, the mechanisms responsible for growth and development of leiomyomas are an enigma. This review provides an overview of current understanding and future directions for clinical and basic research of fibroids.

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