Metabolic Response to Radiation Therapy in Cancer

Overview

Journal Mol Carcinog

Specialties Molecular Biology
Oncology

Date 2021 Dec 28

PMID 34961986

Citations 6

Authors

Graham H Read

Justine Bailleul

Erina Vlashi

Aparna H Kesarwala

Affiliations

Soon will be listed here.

Abstract

Tumor metabolism has emerged as a hallmark of cancer and is involved in carcinogenesis and tumor growth. Reprogramming of tumor metabolism is necessary for cancer cells to sustain high proliferation rates and enhanced demands for nutrients. Recent studies suggest that metabolic plasticity in cancer cells can decrease the efficacy of anticancer therapies by enhancing antioxidant defenses and DNA repair mechanisms. Studying radiation-induced metabolic changes will lead to a better understanding of radiation response mechanisms as well as the identification of new therapeutic targets, but there are few robust studies characterizing the metabolic changes induced by radiation therapy in cancer. In this review, we will highlight studies that provide information on the metabolic changes induced by radiation and oxidative stress in cancer cells and the associated underlying mechanisms.

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