Disease Tolerance During Viral-Bacterial Co-Infections

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Dec 28

PMID 34960631

Citations 5

Authors

Tarani Kanta Barman

Dennis W Metzger

Affiliations

Soon will be listed here.

Abstract

Disease tolerance has emerged as an alternative way, in addition to host resistance, to survive viral-bacterial co-infections. Disease tolerance plays an important role not in reducing pathogen burden, but in maintaining tissue integrity and controlling organ damage. A common co-infection is the synergy observed between influenza virus and that results in superinfection and lethality. Several host cytokines and cells have shown promise in promoting tissue protection and damage control while others induce severe immunopathology leading to high levels of morbidity and mortality. The focus of this review is to describe the host cytokines and innate immune cells that mediate disease tolerance and lead to a return to host homeostasis and ultimately, survival during viral-bacterial co-infection.

Citing Articles

Identification of a genetic region linked to tolerance to MRSA infection using Collaborative Cross mice.

Nagarajan A, Scoggin K, Adams L, Threadgill D, Andrews-Polymenis H PLoS Genet. 2024; 20(8):e1011378.

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Mathematical Modeling of the Lethal Synergism of Coinfecting Pathogens in Respiratory Viral Infections: A Review.

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The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection.

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Clinical Outcomes and Prolonged SARS-CoV-2 Viral Shedding in ICU Patients with Severe COVID-19 Infection and Nosocomial Bacterial Pneumonia: A Retrospective Cohort Study.

Sun C, Feng J, Huang J, Shen H, Chen Y, Chen W J Clin Med. 2022; 11(22).

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Microbial and Immune Regulation of the Gut-Lung Axis during Viral-Bacterial Coinfection.

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