Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose

Overview

Journal Nutrients

Date 2021 Dec 28

PMID 34960045

Citations 7

Authors

Ryota Kobayashi

Miki Sakazaki

Yukie Nagai

Kenji Asaki

Takeo Hashiguchi

Hideyuki Negoro

Affiliations

Soon will be listed here.

Abstract

Increased arterial stiffness during acute hyperglycemia is a risk factor for cardiovascular disease, but the type of carbohydrate that inhibits it is unknown. The purpose of this study was to determine the efficacy of low-glycemic-index isomaltulose on arterial stiffness during hyperglycemia in middle-aged and older adults. Ten healthy middle-aged and older adult subjects orally ingested a solution containing 25 g of isomaltulose (ISI trial) and sucrose (SSI trial) in a crossover study. In the SSI trial, the brachial-ankle (ba) pulse wave velocity (PWV) increased 30, 60, and 90 min after ingestion compared with that before ingestion ( < 0.01); however, in the ISI trial, the baPWV did not change after ingestion compared with that before ingestion. Blood glucose levels 30 min after intake were lower in the ISI trial than in the SSI trial ( < 0.01). The baPWV and systolic blood pressure were positively correlated 90 min after isomaltulose and sucrose ingestion ( = 0.640, < 0.05). These results indicate that isomaltulose intake inhibits an acute increase in arterial stiffness. The results of the present study may have significant clinical implications on the implementation of dietary programs for middle-aged and elderly patients.

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References

Bonora E . Postprandial peaks as a risk factor for cardiovascular disease: epidemiological perspectives. Int J Clin Pract Suppl. 2002; (129):5-11. View

Jacome-Sosa M, Parks E, Bruno R, Tasali E, Lewis G, Schneeman B . Postprandial Metabolism of Macronutrients and Cardiometabolic Risk: Recent Developments, Emerging Concepts, and Future Directions. Adv Nutr. 2016; 7(2):364-74. PMC: 4785471. DOI: 10.3945/an.115.010397. View

Tucker W, Sawyer B, Jarrett C, Bhammar D, Ryder J, Angadi S . High-intensity interval exercise attenuates but does not eliminate endothelial dysfunction after a fast food meal. Am J Physiol Heart Circ Physiol. 2017; 314(2):H188-H194. DOI: 10.1152/ajpheart.00384.2017. View

Lu C, Zou X, Orr W, Chen J . Postprandial changes of sympathovagal balance measured by heart rate variability. Dig Dis Sci. 1999; 44(4):857-61. DOI: 10.1023/a:1026698800742. View

Wolever T, Jenkins D, Ocana A, Rao V, Collier G . Second-meal effect: low-glycemic-index foods eaten at dinner improve subsequent breakfast glycemic response. Am J Clin Nutr. 1988; 48(4):1041-7. DOI: 10.1093/ajcn/48.4.1041. View

Kelsch E, Diana J, Burnet K, Hanson E, Fryer S, Credeur D . Arterial stiffness responses to prolonged sitting combined with a high-glycemic-index meal: a double-blind, randomized crossover trial. J Appl Physiol (1985). 2021; 131(1):229-237. DOI: 10.1152/japplphysiol.00030.2021. View

Kawai K, Okuda Y, Yamashita K . Changes in blood glucose and insulin after an oral palatinose administration in normal subjects. Endocrinol Jpn. 1985; 32(6):933-6. DOI: 10.1507/endocrj1954.32.933. View

Yokoyama H, Shoji T, Kimoto E, Shinohara K, Tanaka S, Koyama H . Pulse wave velocity in lower-limb arteries among diabetic patients with peripheral arterial disease. J Atheroscler Thromb. 2003; 10(4):253-8. DOI: 10.5551/jat.10.253. View

Takei Y, Tomiyama H, Tanaka N, Yamashina A . Close relationship between sympathetic activation and coronary microvascular dysfunction during acute hyperglycemia in subjects with atherosclerotic risk factors. Circ J. 2007; 71(2):202-6. DOI: 10.1253/circj.71.202. View

10.

Tsuboi A, Ito C, Fujikawa R, Yamamoto H, Kihara Y . Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects. Intern Med. 2015; 54(16):1961-9. DOI: 10.2169/internalmedicine.54.3596. View

11.

Kobayashi R, Sato K, Sakazaki M, Nagai Y, Iwanuma S, Ohashi N . Acute effects of difference in glucose intake on arterial stiffness in healthy subjects. Cardiol J. 2019; 28(3):446-452. PMC: 8169176. DOI: 10.5603/CJ.a2019.0108. View

12.

Kobayashi R, Yoshida S, Okamoto T . Arterial stiffness after glucose ingestion in exercise-trained versus untrained men. Appl Physiol Nutr Metab. 2015; 40(11):1151-6. DOI: 10.1139/apnm-2015-0131. View

13.

Kawai K, Yoshikawa H, Murayama Y, Okuda Y, Yamashita K . Usefulness of palatinose as a caloric sweetener for diabetic patients. Horm Metab Res. 1989; 21(6):338-40. DOI: 10.1055/s-2007-1009230. View

14.

Fang F, Liu M, Cheng X, Zhong W, Miao X, Li J . Insulin resistance correlates with the arterial stiffness before glucose intolerance. Intern Med. 2014; 53(3):189-94. DOI: 10.2169/internalmedicine.53.0690. View

15.

Nakao M, Nomura K, Karita K, Nishikitani M, Yano E . Relationship between brachial-ankle pulse wave velocity and heart rate variability in young Japanese men. Hypertens Res. 2005; 27(12):925-31. DOI: 10.1291/hypres.27.925. View

16.

Kobayashi R, Sato K, Takahashi T, Asaki K, Iwanuma S, Ohashi N . Arterial stiffness during hyperglycemia in older adults with high physical activity vs low physical activity. J Clin Biochem Nutr. 2019; 65(2):146-152. PMC: 6769409. DOI: 10.3164/jcbn.19-32. View

17.

Kobayashi R, Sato K, Takahashi T, Asaki K, Iwanuma S, Ohashi N . Effects of a short-term increase in physical activity on arterial stiffness during hyperglycemia. J Clin Biochem Nutr. 2020; 66(3):238-244. PMC: 7263924. DOI: 10.3164/jcbn.19-69. View

18.

Arai H, Ouchi Y, Toba K, Endo T, Shimokado K, Tsubota K . Japan as the front-runner of super-aged societies: Perspectives from medicine and medical care in Japan. Geriatr Gerontol Int. 2015; 15(6):673-87. DOI: 10.1111/ggi.12450. View

19.

Ko G, Wai H, Tang J . Effects of age on plasma glucose levels in non-diabetic Hong Kong Chinese. Croat Med J. 2006; 47(5):709-13. PMC: 2080461. View

20.

. Glucose tolerance and cardiovascular mortality: comparison of fasting and 2-hour diagnostic criteria. Arch Intern Med. 2001; 161(3):397-405. DOI: 10.1001/archinte.161.3.397. View