Application of Photoacoustic Imaging for Lymphedema Treatment

Overview

Journal J Reconstr Microsurg

Date 2021 Dec 27

PMID 34959248

Citations 1

Authors

Yushi Suzuki

Hiroki Kajita

Shiho Watanabe

Keisuke Okabe

Hisashi Sakuma

Nobuaki Imanishi

Sadakazu Aiso

Kazuo Kishi

Affiliations

Soon will be listed here.

Abstract

Background: Lymphatic vessels are difficult to identify using existing modalities as because of their small diameter and the transparency of the lymph fluid flowing through them.

Methods: Here, we introduce photoacoustic lymphangiography (PAL), a new modality widely used for lymphedema treatment, to observe limb lymphatic vessels. The photoacoustic imaging system used in this study can simultaneously visualize lymphatic vessels and veins with a high resolution (0.2 mm) and can also observe their three-dimensional relationship with each other.

Results: High-resolution images of the lymphatic vessels, detailed structure of the dermal back flow, and the three-dimensional positional relationship between the lymphatic vessels and veins were observed by PAL.

Conclusion: The clear image provided by PAL could have a major application in pre- and postoperative use during lymphaticovenular anastomosis for lymphedema treatment.

Citing Articles

Visual inertial odometry enabled 3D ultrasound and photoacoustic imaging.

Sankepalle D, Anthony B, Mallidi S Biomed Opt Express. 2023; 14(6):2756-2772.

PMID: 37342691 PMC: 10278605. DOI: 10.1364/BOE.489614.

References

Hayashi A, Hayashi N, Yoshimatsu H, Yamamoto T . Effective and efficient lymphaticovenular anastomosis using preoperative ultrasound detection technique of lymphatic vessels in lower extremity lymphedema. J Surg Oncol. 2017; 117(2):290-298. DOI: 10.1002/jso.24812. View

Suami H, Taylor G, Pan W . A new radiographic cadaver injection technique for investigating the lymphatic system. Plast Reconstr Surg. 2005; 115(7):2007-13. DOI: 10.1097/01.prs.0000163325.06437.b0. View

Tsuge I, Saito S, Sekiguchi H, Yoshikawa A, Matsumoto Y, Toi M . Photoacoustic Tomography Shows the Branching Pattern of Anterolateral Thigh Perforators In Vivo. Plast Reconstr Surg. 2018; 141(5):1288-1292. DOI: 10.1097/PRS.0000000000004328. View

Maegawa J, Yabuki Y, Tomoeda H, Hosono M, Yasumura K . Outcomes of lymphaticovenous side-to-end anastomosis in peripheral lymphedema. J Vasc Surg. 2012; 55(3):753-60. DOI: 10.1016/j.jvs.2011.08.062. View

Suzuki Y, Kajita H, Kono H, Okabe K, Sakuma H, Imanishi N . The Direct Observation of Lymphaticovenular Anastomosis Patency with Photoacoustic Lymphangiography. Plast Reconstr Surg Glob Open. 2021; 9(1):e3348. PMC: 7858285. DOI: 10.1097/GOX.0000000000003348. View

Giacalone G, Yamamoto T, Belva F, Hayashi A . Bedside 3D Visualization of Lymphatic Vessels with a Handheld Multispectral Optoacoustic Tomography Device. J Clin Med. 2020; 9(3). PMC: 7141284. DOI: 10.3390/jcm9030815. View

Maegawa J, Mikami T, Yamamoto Y, Satake T, Kobayashi S . Types of lymphoscintigraphy and indications for lymphaticovenous anastomosis. Microsurgery. 2010; 30(6):437-42. DOI: 10.1002/micr.20772. View

Suzuki Y, Sakuma H, Yamazaki S . Evaluation of patency rates of different lymphaticovenous anastomosis techniques and risk factors for obstruction in secondary upper extremity lymphedema. J Vasc Surg Venous Lymphat Disord. 2018; 7(1):113-117. DOI: 10.1016/j.jvsv.2018.05.030. View

Neligan P, Kung T, Maki J . MR lymphangiography in the treatment of lymphedema. J Surg Oncol. 2016; 115(1):18-22. DOI: 10.1002/jso.24337. View

10.

Hara H, Mihara M, Seki Y, Todokoro T, Iida T, Koshima I . Comparison of indocyanine green lymphographic findings with the conditions of collecting lymphatic vessels of limbs in patients with lymphedema. Plast Reconstr Surg. 2013; 132(6):1612-1618. DOI: 10.1097/PRS.0b013e3182a97edc. View

11.

Mihara M, Hara H, Kawakami Y . Ultrasonography for classifying lymphatic sclerosis types and deciding optimal sites for lymphatic-venous anastomosis in patients with lymphoedema<sup/>. J Plast Reconstr Aesthet Surg. 2018; 71(9):1274-1281. DOI: 10.1016/j.bjps.2018.05.012. View

12.

Narushima M, Yamamoto T, Ogata F, Yoshimatsu H, Mihara M, Koshima I . Indocyanine Green Lymphography Findings in Limb Lymphedema. J Reconstr Microsurg. 2015; 32(1):72-9. DOI: 10.1055/s-0035-1564608. View

13.

Mihara M, Hara H, Tange S, Zhou H, Kawahara M, Shimizu Y . Multisite Lymphaticovenular Bypass Using Supermicrosurgery Technique for Lymphedema Management in Lower Lymphedema Cases. Plast Reconstr Surg. 2016; 138(1):262-272. DOI: 10.1097/PRS.0000000000002254. View

14.

Ruehm S, Schroeder T, Debatin J . Interstitial MR lymphography with gadoterate meglumine: initial experience in humans. Radiology. 2001; 220(3):816-21. DOI: 10.1148/radiol.2203010090. View

15.

Suzuki Y, Sakuma H, Yamazaki S . Comparison of patency rates of lymphaticovenous anastomoses at different sites for lower extremity lymphedema. J Vasc Surg Venous Lymphat Disord. 2019; 7(2):222-227. DOI: 10.1016/j.jvsv.2018.10.022. View

16.

Yasunaga Y, Nakajima Y, Mimura S, Yuzuriha S, Kondoh S . Magnetic resonance lymphography as three-dimensional navigation for lymphaticovenular anastomosis in patients with leg lymphedema. J Plast Reconstr Aesthet Surg. 2020; 74(6):1253-1260. DOI: 10.1016/j.bjps.2020.10.099. View

17.

Yamamoto T, Yamamoto N, Yamashita M, Furuya M, Hayashi A, Koshima I . Efferent Lymphatic Vessel Anastomosis: Supermicrosurgical Efferent Lymphatic Vessel-to-Venous Anastomosis for the Prophylactic Treatment of Subclinical Lymphedema. Ann Plast Surg. 2014; 76(4):424-7. DOI: 10.1097/SAP.0000000000000381. View

18.

Suzuki Y, Kajita H, Oh A, Takemaru M, Sakuma H, Tsuji T . Use of photoacoustic imaging to determine the effects of aging on lower extremity lymphatic vessel function. J Vasc Surg Venous Lymphat Disord. 2021; 10(1):125-130. DOI: 10.1016/j.jvsv.2021.05.001. View

19.

Tsuge I, Saito S, Yamamoto G, Sekiguchi H, Yoshikawa A, Matsumoto Y . Preoperative vascular mapping for anterolateral thigh flap surgeries: A clinical trial of photoacoustic tomography imaging. Microsurgery. 2019; 40(3):324-330. DOI: 10.1002/micr.30531. View

20.

Kajita H, Oh A, Urano M, Takemaru M, Imanishi N, Otaki M . Photoacoustic lymphangiography. J Surg Oncol. 2019; 121(1):48-50. DOI: 10.1002/jso.25575. View