Whole-genome Analysis of Haemophilus Influenzae Invasive Strains Isolated from Campinas State University Hospital. An Epidemiological Approach 2012 - 2019 and Ancestor Strains

Overview

Journal Braz J Infect Dis

Specialty Infectious Diseases

Date 2021 Dec 27

PMID 34958740

Authors

Rafaella Fabiana Carneiro Pereira

Joao Paulo de Oliveira Guarnieri

Carlos Fernando Macedo da Silva

Bruno Gaia Bernardes

Marcelo Lancellotti

Affiliations

Soon will be listed here.

Abstract

Thirteen Haemophylus influenzae invasive strains isolated from patients at Clinical Hospital of State University of Campinas, from May 2013 through August 2019, was submitted to Illumina genome sequencing HiSeq platform. Further in silico analysis of serogroup and Multi Locus Sequence Typing (MLST) from whole DNA sequencing had demonstrated the actual clonal distribution in the Campinas Metropolitan region. Thus, results showed the existence of a new ST Haemophilus influenzae found in the Brazilian territory and an increase of strains belonging to serogroup a (three strains also belonging to ST23). In conclusion, we observed an increase of non-typable H. influenzae (NTHi) and a strain involved in invasive diseases in the Campinas - São Paulo region after frequent detection of those serotypes and genotypes in other Brazilian regions.

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