Is It Hyperfibrinolysis or Fibrinolytic Shutdown in Severe COVID-19?

Overview

Journal Thromb Res

Date 2021 Dec 25

PMID 34953317

Citations 7

Authors

Nathan D Nielsen

Marian A Rollins-Raval

Jay S Raval

Jecko Thachil

Affiliations

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Citing Articles

Fibrinolytic Changes in Critical Illnesses: Is Fibrinolysis Shutdown a Specific Concept?.

Levy J, Iba T Juntendo Iji Zasshi. 2025; 70(6):416-419.

PMID: 39839999 DOI: 10.14789/ejmj.JMJ24-0035-P.

Immunity and Coagulation in COVID-19.

Avdonin P, Blinova M, Serkova A, Komleva L, Avdonin P Int J Mol Sci. 2024; 25(20).

PMID: 39457048 PMC: 11508857. DOI: 10.3390/ijms252011267.

Case Report: First attempt by off-label use of tenecteplase to treat acute extensive portal venous system thrombosis.

Li Q, Piao Y, Zhang Y, Qi X Front Cardiovasc Med. 2024; 11:1342529.

PMID: 38455718 PMC: 10917880. DOI: 10.3389/fcvm.2024.1342529.

Mechanisms of endothelial activation, hypercoagulation and thrombosis in COVID-19: a link with diabetes mellitus.

Valencia I, Lumpuy-Castillo J, Magalhaes G, Sanchez-Ferrer C, Lorenzo O, Peiro C Cardiovasc Diabetol. 2024; 23(1):75.

PMID: 38378550 PMC: 10880237. DOI: 10.1186/s12933-023-02097-8.

Novel Tissue Factor Inhibition for Thromboprophylaxis in COVID-19: Primary Results of the ASPEN-COVID-19 Trial.

Hess C, Hsia J, Carroll I, Nehler M, Ruf W, Morrow D Arterioscler Thromb Vasc Biol. 2023; 43(8):1572-1582.

PMID: 37381988 PMC: 10364965. DOI: 10.1161/ATVBAHA.122.318748.

References

Weiss E, Roux O, Moyer J, Paugam-Burtz C, Boudaoud L, Ajzenberg N . Fibrinolysis Resistance: A Potential Mechanism Underlying COVID-19 Coagulopathy. Thromb Haemost. 2020; 120(9):1343-1345. DOI: 10.1055/s-0040-1713637. View

Nougier C, Benoit R, Simon M, Desmurs-Clavel H, Marcotte G, Argaud L . Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis. J Thromb Haemost. 2020; 18(9):2215-2219. PMC: 7405476. DOI: 10.1111/jth.15016. View

Thachil J, Juffermans N, Ranucci M, Connors J, Warkentin T, Ortel T . ISTH DIC subcommittee communication on anticoagulation in COVID-19. J Thromb Haemost. 2020; 18(9):2138-2144. PMC: 7404846. DOI: 10.1111/jth.15004. View

Bachler M, Bosch J, Sturzel D, Hell T, Giebl A, Strohle M . Impaired fibrinolysis in critically ill COVID-19 patients. Br J Anaesth. 2021; 126(3):590-598. PMC: 7833514. DOI: 10.1016/j.bja.2020.12.010. View

Heinz C, Miesbach W, Herrmann E, Sonntagbauer M, Raimann F, Zacharowski K . Greater Fibrinolysis Resistance but No Greater Platelet Aggregation in Critically Ill COVID-19 Patients. Anesthesiology. 2021; 134(3):457-467. PMC: 7864605. DOI: 10.1097/ALN.0000000000003685. View