Osteosarcopenia School

Overview

Journal J Frailty Sarcopenia Falls

Date 2021 Dec 24

PMID 34950814

Citations 1

Authors

Yannis Dionyssiotis

Konstantinos Prokopidis

Panagiotis Vorniotakis

Eleftherios Bakas

Affiliations

Soon will be listed here.

Abstract

Osteosarcopenia has been proposed as a syndrome in a subset of frail individuals at higher risk of falls, fractures and institutionalization. In this paper, we will go over the translational aspects of sarcopenia and osteoporosis research and highlight outcomes from different interventions. In addition, preventative measures and therapeutic interventions that can benefit both muscle and bone simultaneously will be analysed also. A new holistic concept called Osteosarcopenia School will be presented. This new concept is based on counselling and education of patients as part of a rehabilitation program, aiming to reduce the risk of social isolation, falls and fractures, and subsequent disability through muscle strengthening and balance training. In this patient group, the combination of pharmaceutical treatments and specific exercise programmes are essential to counteract the consequences of osteosarcopenia. Finally, educational programmes targeting patient functionality through social reintegration may have a substantial impact on their daily living activities and overall quality of life.

Citing Articles

The Effects of the 'Catabolic Crisis' on Patients' Prolonged Immobility after COVID-19 Infection.

Moga T, Nistor-Cseppento C, Bungau S, Tit D, Sabau A, Behl T Medicina (Kaunas). 2022; 58(6).

PMID: 35744091 PMC: 9231342. DOI: 10.3390/medicina58060828.

References

Frost H . Bone's mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol. 2003; 275(2):1081-101. DOI: 10.1002/ar.a.10119. View

. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994; 843:1-129. View

Yoo J, Ha Y, Kwon H, Lee Y, Koo K, Yoo M . High Prevalence of Sarcopenia in Korean Patients after Hip Fracture: a Case-Control Study. J Korean Med Sci. 2016; 31(9):1479-84. PMC: 4974192. DOI: 10.3346/jkms.2016.31.9.1479. View

Kelly R, McDonald L, Jensen N, Sidles S, LaRue A . Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions. Front Psychiatry. 2019; 10:200. PMC: 6465575. DOI: 10.3389/fpsyt.2019.00200. View

Chen L, Liu L, Woo J, Assantachai P, Auyeung T, Bahyah K . Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc. 2014; 15(2):95-101. DOI: 10.1016/j.jamda.2013.11.025. View

Fielding R, Vellas B, Evans W, Bhasin S, Morley J, Newman A . Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011; 12(4):249-56. PMC: 3377163. DOI: 10.1016/j.jamda.2011.01.003. View

Morley J, Abbatecola A, Argiles J, Baracos V, Bauer J, Bhasin S . Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc. 2011; 12(6):403-9. PMC: 5100674. DOI: 10.1016/j.jamda.2011.04.014. View

Isidori A, Giannetta E, Greco E, Gianfrilli D, Bonifacio V, Isidori A . Effects of testosterone on body composition, bone metabolism and serum lipid profile in middle-aged men: a meta-analysis. Clin Endocrinol (Oxf). 2005; 63(3):280-93. DOI: 10.1111/j.1365-2265.2005.02339.x. View

Johnson K, Suriyaarachchi P, Kakkat M, Boersma D, Gunawardene P, Demontiero O . Yield and cost-effectiveness of laboratory testing to identify metabolic contributors to falls and fractures in older persons. Arch Osteoporos. 2015; 10:226. DOI: 10.1007/s11657-015-0226-3. View

10.

Duque G, Daly R, Sanders K, Kiel D . Vitamin D, bones and muscle: myth versus reality. Australas J Ageing. 2017; 36 Suppl 1:8-13. DOI: 10.1111/ajag.12408. View

11.

Becker C, Lord S, Studenski S, Warden S, Fielding R, Recknor C . Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial. Lancet Diabetes Endocrinol. 2015; 3(12):948-57. DOI: 10.1016/S2213-8587(15)00298-3. View

12.

Fatima M, Brennan-Olsen S, Duque G . Therapeutic approaches to osteosarcopenia: insights for the clinician. Ther Adv Musculoskelet Dis. 2019; 11:1759720X19867009. PMC: 6686316. DOI: 10.1177/1759720X19867009. View

13.

Huo Y, Suriyaarachchi P, Gomez F, Curcio C, Boersma D, Muir S . Phenotype of osteosarcopenia in older individuals with a history of falling. J Am Med Dir Assoc. 2014; 16(4):290-5. DOI: 10.1016/j.jamda.2014.10.018. View

14.

Woo J, Leung J, Morley J . Validating the SARC-F: a suitable community screening tool for sarcopenia?. J Am Med Dir Assoc. 2014; 15(9):630-4. DOI: 10.1016/j.jamda.2014.04.021. View

15.

Phu S, Boersma D, Duque G . Exercise and Sarcopenia. J Clin Densitom. 2015; 18(4):488-92. DOI: 10.1016/j.jocd.2015.04.011. View

16.

Bani Hassan E, Duque G . Osteosarcopenia: A new geriatric syndrome. Aust Fam Physician. 2017; 46(11):849-853. View

17.

Bhasin S, Calof O, Storer T, Lee M, Mazer N, Jasuja R . Drug insight: Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. Nat Clin Pract Endocrinol Metab. 2006; 2(3):146-59. PMC: 2072878. DOI: 10.1038/ncpendmet0120. View

18.

Daly R . Exercise and nutritional approaches to prevent frail bones, falls and fractures: an update. Climacteric. 2017; 20(2):119-124. DOI: 10.1080/13697137.2017.1286890. View

19.

Sepulveda-Loyola W, Phu S, Bani Hassan E, Brennan-Olsen S, Zanker J, Vogrin S . The Joint Occurrence of Osteoporosis and Sarcopenia (Osteosarcopenia): Definitions and Characteristics. J Am Med Dir Assoc. 2019; 21(2):220-225. DOI: 10.1016/j.jamda.2019.09.005. View

20.

Kawao N, Kaji H . Interactions between muscle tissues and bone metabolism. J Cell Biochem. 2014; 116(5):687-95. DOI: 10.1002/jcb.25040. View