Feasibility and Added Value of Fetal DTI Tractography in the Evaluation of an Isolated Short Corpus Callosum: Preliminary Results

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2021 Dec 24

PMID 34949593

Citations 4

Authors

A-E Millischer

D Grevent

P Sonigo

N Bahi-Buisson

I Desguerre

H Mahallati

J-P Bault

T Quibel

S Couderc

M-L Moutard

E Julien

V Dangouloff

B Bessieres

V Malan

T Attie

L-J Salomon

N Boddaert

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Prognosis of isolated short corpus callosum is challenging. Our aim was to assess whether fetal DTI tractography can distinguish callosal dysplasia from variants of normal callosal development in fetuses with an isolated short corpus callosum.

Materials And Methods: This was a retrospective study of 37 cases referred for fetal DTI at 30.4 weeks (range, 25-34 weeks) because of an isolated short corpus callosum less than the 5th percentile by sonography at 26 weeks (range, 22-31 weeks). Tractography quality, the presence of Probst bundles, dysmorphic frontal horns, callosal length (internal cranial occipitofrontal dimension/length of the corpus callosum ratio), and callosal thickness were assessed. Cytogenetic data and neurodevelopmental follow-up were systematically reviewed.

Results: Thirty-three of 37 fetal DTIs distinguished the 2 groups: those with Probst bundles (Probst bundles+) in 13/33 cases (40%) and without Probst bundles (Probst bundles-) in 20/33 cases (60%). Internal cranial occipitofrontal dimension/length of the corpus callosum was significantly higher in Probst bundles+ than in Probst bundles-, with a threshold value determined at 3.75 for a sensitivity of 92% (95% CI, 77%-100%) and specificity of 85% (95% CI, 63%-100%). Callosal lipomas (4/4) were all in the Probst bundles- group. More genetic anomalies were found in the Probst bundles+ than in Probst bundles- group (23% versus 10%, = .08).

Conclusions: Fetal DTI, combined with anatomic, cytogenetic, and clinical characteristics could suggest the possibility of classifying an isolated short corpus callosum as callosal dysplasia and a variant of normal callosal development.

Citing Articles

White Matter Tract Crossing and Bottleneck Regions in the Fetal Brain.

Calixto C, Soldatelli M, Li B, Vasung L, Jaimes C, Gholipour A Hum Brain Mapp. 2025; 46(1):e70132.

PMID: 39812160 PMC: 11733681. DOI: 10.1002/hbm.70132.

Assessing the Agreement Between Diffusion Tension Imaging (DTI) and T2-Weighted MRI Sequence for Biometry of the Fetal Corpus Callosum.

Cohn L, Bookstein S, Laytman Klein T, Mordenfeld Kozlovsky N, Ziv-Baran T, Mayer A Diagnostics (Basel). 2024; 14(23).

PMID: 39682608 PMC: 11640407. DOI: 10.3390/diagnostics14232700.

White matter tract crossing and bottleneck regions in the fetal brain.

Calixto C, Soldatelli M, Li B, Pierotich L, Gholipour A, Warfield S bioRxiv. 2024; .

PMID: 39091823 PMC: 11291018. DOI: 10.1101/2024.07.20.603804.

Anatomically constrained tractography of the fetal brain.

Calixto C, Jaimes C, Soldatelli M, Warfield S, Gholipour A, Karimi D Neuroimage. 2024; 297:120723.

PMID: 39029605 PMC: 11382095. DOI: 10.1016/j.neuroimage.2024.120723.

Assessment of fetal corpus callosum biometry by 3D super-resolution reconstructed T2-weighted magnetic resonance imaging.

Lamon S, De Dumast P, Sanchez T, Dunet V, Pomar L, Vial Y Front Neurol. 2024; 15:1358741.

PMID: 38595845 PMC: 11002102. DOI: 10.3389/fneur.2024.1358741.

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