Provokes Seminal Inflammation Among Infertile Males

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Dec 24

PMID 34948264

Citations 4

Authors

Stanislav Tjagur

Reet Mandar

Olev Poolamets

Kristjan Pomm

Margus Punab

Affiliations

Soon will be listed here.

Abstract

The impact of sexually transmitted infections (STI) on male fertility is controversial. Aims: To investigate the prevalence of urethritis-associated STIs (chlamydia, gonorrhoeae, , trichomoniasis) among infertile males; to analyze the effect of STIs on semen parameters and blood PSA. Case-control study. Study group ( = 2000): males with fertility problems or desire for fertility check. Control group ( = 248): male partners of pregnant women. Analyses: polymerase chain reaction for STI, seminal interleukin 6 (IL-6), semen and fractionated urine, blood analyses (PSA, reproductive hormones). The prevalence of and chlamydia in the study group was 1.1% and 1.2%, respectively. The prevalence of chlamydia in the control group was 1.6%, while there were no cases. No cases with gonorrhoeae or trichomoniasis or combined infections were observed in neither group. There was a higher seminal concentration of neutrophils and IL-6 among positives compared with STI negatives. There was a trend toward a lower total count of spermatozoa and progressive motility among STI positives. No impact of STIs on PSA was found. The prevalence of STIs among infertile males is low. is associated with seminal inflammation. The impact of STIs on semen parameters deserves further investigations.

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References

Boivin J, Bunting L, Collins J, Nygren K . International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod. 2007; 22(6):1506-12. DOI: 10.1093/humrep/dem046. View

Kopa Z, Wenzel J, Papp G, Haidl G . Role of granulocyte elastase and interleukin-6 in the diagnosis of male genital tract inflammation. Andrologia. 2005; 37(5):188-94. DOI: 10.1111/j.1439-0272.2005.00676.x. View

Mo X, Zhu C, Gan J, Wang C, Wei F, Gong W . Prevalence and correlates of Mycoplasma genitalium infection among prostatitis patients in Shanghai, China. Sex Health. 2016; . DOI: 10.1071/SH15155. View

Motrich R, Cuffini C, Oberti J, Maccioni M, Rivero V . Chlamydia trachomatis occurrence and its impact on sperm quality in chronic prostatitis patients. J Infect. 2005; 53(3):175-83. DOI: 10.1016/j.jinf.2005.11.007. View

Hosseinzadeh S, Eley A, Pacey A . Semen quality of men with asymptomatic chlamydial infection. J Androl. 2003; 25(1):104-9. DOI: 10.1002/j.1939-4640.2004.tb02764.x. View

Taylor-Robinson D, Jensen J . Mycoplasma genitalium: from Chrysalis to multicolored butterfly. Clin Microbiol Rev. 2011; 24(3):498-514. PMC: 3131060. DOI: 10.1128/CMR.00006-11. View

Dieterle S, Mahony J, Luinstra K, Stibbe W . Chlamydial immunoglobulin IgG and IgA antibodies in serum and semen are not associated with the presence of Chlamydia trachomatis DNA or rRNA in semen from male partners of infertile couples. Hum Reprod. 1995; 10(2):315-9. DOI: 10.1093/oxfordjournals.humrep.a135934. View

Gimenes F, Medina F, de Abreu A, Irie M, Esquicati I, Malagutti N . Sensitive simultaneous detection of seven sexually transmitted agents in semen by multiplex-PCR and of HPV by single PCR. PLoS One. 2014; 9(6):e98862. PMC: 4055596. DOI: 10.1371/journal.pone.0098862. View

Weidner W, Pilatz A, Diemer T, Schuppe H, Rusz A, Wagenlehner F . Male urogenital infections: impact of infection and inflammation on ejaculate parameters. World J Urol. 2013; 31(4):717-23. DOI: 10.1007/s00345-013-1082-7. View

10.

Plecko V, Zele-Starcevic L, Tripkovic V, Skerlev M, Ljubojevic S, Plesko S . Unusually low prevalence of Mycoplasma genitalium in urine samples from infertile men and healthy controls: a prevalence study. BMJ Open. 2014; 4(8):e005372. PMC: 4156801. DOI: 10.1136/bmjopen-2014-005372. View

11.

de Barbeyrac B, Papaxanthos-Roche A, Mathieu C, Germain C, Brun J, Gachet M . Chlamydia trachomatis in subfertile couples undergoing an in vitro fertilization program: a prospective study. Eur J Obstet Gynecol Reprod Biol. 2006; 129(1):46-53. DOI: 10.1016/j.ejogrb.2006.02.014. View

12.

Gdoura R, Kchaou W, Znazen A, Chakroun N, Fourati M, Ammar-Keskes L . Screening for bacterial pathogens in semen samples from infertile men with and without leukocytospermia. Andrologia. 2008; 40(4):209-18. DOI: 10.1111/j.1439-0272.2008.00845.x. View

13.

Kokab A, Akhondi M, Sadeghi M, Modarresi M, Aarabi M, Jennings R . Raised inflammatory markers in semen from men with asymptomatic chlamydial infection. J Androl. 2009; 31(2):114-20. DOI: 10.2164/jandrol.109.008300. View

14.

Huang C, Zhu H, Xu K, Wang S, Fan L, Zhu W . Mycoplasma and ureaplasma infection and male infertility: a systematic review and meta-analysis. Andrology. 2015; 3(5):809-16. DOI: 10.1111/andr.12078. View

15.

Weidner W, Diemer T, Huwe P, Rainer H, Ludwig M . The role of Chlamydia trachomatis in prostatitis. Int J Antimicrob Agents. 2002; 19(6):466-70. DOI: 10.1016/s0924-8579(02)00094-8. View

16.

Ochsendorf F . Sexually transmitted infections: impact on male fertility. Andrologia. 2008; 40(2):72-5. DOI: 10.1111/j.1439-0272.2007.00825.x. View

17.

Redgrove K, McLaughlin E . The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword. Front Immunol. 2014; 5:534. PMC: 4209867. DOI: 10.3389/fimmu.2014.00534. View

18.

Mielczarek E, Blaszkowska J . Trichomonas vaginalis: pathogenicity and potential role in human reproductive failure. Infection. 2015; 44(4):447-58. DOI: 10.1007/s15010-015-0860-0. View

19.

Zegers-Hochschild F, Adamson G, de Mouzon J, Ishihara O, Mansour R, Nygren K . International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009; 92(5):1520-4. DOI: 10.1016/j.fertnstert.2009.09.009. View

20.

Korrovits P, Ausmees K, Mandar R, Punab M . Seminal interleukin-6 and serum prostate-specific antigen as possible predictive biomarkers in asymptomatic inflammatory prostatitis. Urology. 2011; 78(2):442-6. DOI: 10.1016/j.urology.2011.02.013. View