NLRP3 Inflammasome in Diabetic Cardiomyopathy and Exercise Intervention

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2021 Dec 24

PMID 34948026

Citations 26

Authors

Yi Sun

Shuzhe Ding

Affiliations

Soon will be listed here.

Abstract

Diabetic cardiomyopathy (DCM), as a common complication of diabetes, is characterized by chronic low-grade inflammation. The NLRP3 inflammasome is a key sensor mediating innate immune and inflammatory responses. However, the mechanisms initiating and promoting NLRP3 inflammasome activation in DCM is largely unexplored. The aim of the present review is to describe the link between NLRP3 inflammasome and DCM, and to provide evidence highlighting the importance of exercise training in DCM intervention. Collectively, this evidence suggests that DCM is an inflammatory disease aggravated by NLRP3 inflammasome-mediated release of IL-1β and IL-18. In addition, chronic exercise intervention is an effective preventive and therapeutic method to alleviate DCM via modulating the NLRP3 inflammasome.

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References

Kristiansen S, Skovsted G, Berchtold L, Radziwon-Balicka A, Dreisig K, Edvinsson L . Role of pannexin and adenosine triphosphate (ATP) following myocardial ischemia/reperfusion. Scand Cardiovasc J. 2018; 52(6):340-343. DOI: 10.1080/14017431.2018.1552793. View

Mardare C, Kruger K, Liebisch G, Seimetz M, Couturier A, Ringseis R . Endurance and Resistance Training Affect High Fat Diet-Induced Increase of Ceramides, Inflammasome Expression, and Systemic Inflammation in Mice. J Diabetes Res. 2016; 2016:4536470. PMC: 4691630. DOI: 10.1155/2016/4536470. View

Hansen D, Coninx K, Dendale P . The EAPC EXPERT tool. Eur Heart J. 2017; 38(30):2318-2320. DOI: 10.1093/eurheartj/ehx396. View

Everett B, Cornel J, Lainscak M, Anker S, Abbate A, Thuren T . Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure. Circulation. 2018; 139(10):1289-1299. DOI: 10.1161/CIRCULATIONAHA.118.038010. View

Boule N, Haddad E, Kenny G, Wells G, Sigal R . Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001; 286(10):1218-27. DOI: 10.1001/jama.286.10.1218. View

Li S, Culver B, Ren J . Benefit and risk of exercise on myocardial function in diabetes. Pharmacol Res. 2003; 48(2):127-32. DOI: 10.1016/s1043-6618(03)00099-9. View

Fontanils U, Seil M, Pochet S, El Ouaaliti M, Garcia-Marcos M, Dehaye J . Stimulation by P2X₇ receptors of calcium-dependent production of reactive oxygen species (ROS) in rat submandibular glands. Biochim Biophys Acta. 2010; 1800(11):1183-91. DOI: 10.1016/j.bbagen.2010.07.007. View

Carlos D, Costa F, Pereira C, Rocha F, Yaochite J, Oliveira G . Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model. Front Immunol. 2017; 8:164. PMC: 5326761. DOI: 10.3389/fimmu.2017.00164. View

Vigano E, Diamond C, Spreafico R, Balachander A, Sobota R, Mortellaro A . Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun. 2015; 6:8761. PMC: 4640152. DOI: 10.1038/ncomms9761. View

10.

Taniguchi S, Sagara J . Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC. Semin Immunopathol. 2007; 29(3):231-8. DOI: 10.1007/s00281-007-0082-3. View

11.

Zile M, Brutsaert D . New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. Circulation. 2002; 105(11):1387-93. DOI: 10.1161/hc1102.105289. View

12.

Pedersen B . Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease. Eur J Clin Invest. 2017; 47(8):600-611. DOI: 10.1111/eci.12781. View

13.

Takeuchi O, Akira S . Pattern recognition receptors and inflammation. Cell. 2010; 140(6):805-20. DOI: 10.1016/j.cell.2010.01.022. View

14.

Wang X, Pan J, Liu H, Zhang M, Liu D, Lu L . AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model. Life Sci. 2019; 221:249-258. DOI: 10.1016/j.lfs.2019.02.035. View

15.

Crisafulli A, Pagliaro P, Roberto S, Cugusi L, Mercuro G, Lazou A . Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning. Int J Mol Sci. 2020; 21(8). PMC: 7215312. DOI: 10.3390/ijms21082896. View

16.

Hayat S, Patel B, Khattar R, Malik R . Diabetic cardiomyopathy: mechanisms, diagnosis and treatment. Clin Sci (Lond). 2004; 107(6):539-57. DOI: 10.1042/CS20040057. View

17.

Kayagaki N, Wong M, Stowe I, Ramani S, Gonzalez L, Akashi-Takamura S . Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science. 2013; 341(6151):1246-9. DOI: 10.1126/science.1240248. View

18.

Hu F, Stampfer M, Solomon C, Liu S, Colditz G, Speizer F . Physical activity and risk for cardiovascular events in diabetic women. Ann Intern Med. 2001; 134(2):96-105. DOI: 10.7326/0003-4819-134-2-200101160-00009. View

19.

Chen Y, Hua Y, Li X, Muhammad Arslan I, Zhang W, Meng G . Distinct Types of Cell Death and the Implication in Diabetic Cardiomyopathy. Front Pharmacol. 2020; 11:42. PMC: 7018666. DOI: 10.3389/fphar.2020.00042. View

20.

Dror E, Dalmas E, Meier D, Wueest S, Thevenet J, Thienel C . Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol. 2017; 18(3):283-292. DOI: 10.1038/ni.3659. View