, a Novel Member of with Multidrug Resistance, Exhibits Cytotoxicity

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2021 Dec 24

PMID 34943744

Authors

Chao Wang

Yuan Zeng

Mengyu Wei

Lanqing Cui

Yuqin Song

Gang Zhang

Yun Li

Jie Feng

Affiliations

Soon will be listed here.

Abstract

We describe the genomic and phenotypic characteristics of a novel member of with multidrug resistance (MDR) isolated from hospital samples. Strains SP218 and SP219 were identified as a novel , . , using whole-genome sequencing and biochemical tests. Average nucleotide identity values of strains SP218 and SP219 with . IS7493 and ST556 were 94.3% and 93.3%, respectively. Genome-to-genome distance values of strains SP218 and SP219 with . IS7493 and ST556 were 56.70% (54-59.5%) and 56.40% (52.8-59.9%), respectively. The biochemical test results distinguished these strains from . and , particularly hydrolysis of equine urate and utilization of ribose to produce acid. These isolates were resistant to six major classes of antibiotics, which correlated with horizontal gene transfer and mutation. Notably, strain SP219 exhibited cytotoxicity against human lung epithelial cell line A549. Our results indicate the pathogenic potential of . , and provide valuable insights into mitis group of streptococci.

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