Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

Overview

Journal Antioxidants (Basel)

Date 2021 Dec 24

PMID 34942989

Citations 61

Authors

Matyas Jelinek

Michal Jurajda

Kamil Duris

Affiliations

Soon will be listed here.

Abstract

The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, free radicals are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the production and elimination of free radicals under pathological conditions. Oxidative stress is also associated with ageing. The brain is prone to oxidative damage because of its high metabolic activity and high vulnerability to ischemic damage. Oxidative stress, thus, plays a major role in the pathophysiology of both acute and chronic pathologies in the brain, such as stroke, traumatic brain injury or neurodegenerative diseases. The goal of this article is to summarize the basic concepts of oxidative stress and its significance in brain pathologies, as well as to discuss treatment strategies for dealing with oxidative stress in stroke.

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