Immunocytological Study of Phlyctenular Eye Disease

Overview

Journal Int Ophthalmol

Specialty Ophthalmology

Date 1987 Feb 1

PMID 3493984

Citations 2

Authors

A M Abu El Asrar

K Geboes

P C Maudgal

M H EMARAH

L Missotten

V Desmet

Affiliations

Soon will be listed here.

Abstract

Scrapings from phlyctens and conjunctiva of 12 patients with phlyctenular keratoconjunctivitis were studied using OKT4-Leu3a, OKT8, B1, BA1, S-100 and HLA-DR monoclonal antibodies. T-lymphocytes were present in both conjunctival and phlyctenular scrapings. OKT4-Leu3a positive cells outnumbered the OKT8 positive cells in both conjunctival and phlyctenular scrapings. B1 and BA1 positive cells were absent from the conjunctival scrapings, but were present in the phlyctenular scrapings. S-100 positive cells were present in both conjunctival and phlyctenular scrapings. However, they were very few in the conjunctival scrapings. Most of the cells in both conjunctival and phlyctenular scrapings were HLA-DR positive. These findings support the hypothesis that cell mediated immunity is responsible for the pathogenesis of phlyctenular eye disease.

Citing Articles

Pediatric Phlyctenular Keratoconjunctivitis at a Tertiary Care Center in the United States.

Kaufman A, Chhadva P, Bontu S, Bueno C, Jain S, Tu E Cornea. 2023; 42(9):1083-1091.

PMID: 36731094 PMC: 10050225. DOI: 10.1097/ICO.0000000000003112.

Phenotypic characterization of inflammatory cells in phlyctenular eye disease.

Abu El-Asrar A, van den Oord J, Geboes K, Facchetti F, Missotten L, EMARAH M Doc Ophthalmol. 1988; 70(4):353-62.

PMID: 3075177 DOI: 10.1007/BF00157065.

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