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BOOSTED NONPARAMETRIC HAZARDS WITH TIME-DEPENDENT COVARIATES

Overview
Journal Ann Stat
Specialty Public Health
Date 2021 Dec 23
PMID 34937956
Citations 6
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Abstract

Given functional data from a survival process with time-dependent covariates, we derive a smooth convex representation for its nonparametric log-likelihood functional and obtain its functional gradient. From this we devise a generic gradient boosting procedure for estimating the hazard function nonparametrically. An illustrative implementation of the procedure using regression trees is described to show how to recover the unknown hazard. The generic estimator is consistent if the model is correctly specified; alternatively an oracle inequality can be demonstrated for tree-based models. To avoid overfitting, boosting employs several regularization devices. One of them is step-size restriction, but the rationale for this is somewhat mysterious from the viewpoint of consistency. Our work brings some clarity to this issue by revealing that step-size restriction is a mechanism for preventing the curvature of the risk from derailing convergence.

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References
1.
Adelson K, Lee D, Velji S, Ma J, Lipka S, Rimar J . Development of Imminent Mortality Predictor for Advanced Cancer (IMPAC), a Tool to Predict Short-Term Mortality in Hospitalized Patients With Advanced Cancer. J Oncol Pract. 2017; 14(3):e168-e175. DOI: 10.1200/JOP.2017.023200. View

2.
Binder H, Schumacher M . Allowing for mandatory covariates in boosting estimation of sparse high-dimensional survival models. BMC Bioinformatics. 2008; 9:14. PMC: 2245904. DOI: 10.1186/1471-2105-9-14. View

3.
Schmid M, Hothorn T . Flexible boosting of accelerated failure time models. BMC Bioinformatics. 2008; 9:269. PMC: 2453145. DOI: 10.1186/1471-2105-9-269. View

4.
Huang J, Ma S, Xie H . Regularized estimation in the accelerated failure time model with high-dimensional covariates. Biometrics. 2006; 62(3):813-20. DOI: 10.1111/j.1541-0420.2006.00562.x. View

5.
Hothorn T, Buhlmann P, Dudoit S, Molinaro A, van der Laan M . Survival ensembles. Biostatistics. 2005; 7(3):355-73. DOI: 10.1093/biostatistics/kxj011. View