CD99 Antibody Disrupts T-cell Acute Lymphoblastic Leukemia Adhesion to Meningeal Cells and Attenuates Chemoresistance

Overview

Journal Sci Rep

Specialty Science

Date 2021 Dec 22

PMID 34934147

Citations 4

Authors

Maryam Ebadi

Leslie M Jonart

Jason Ostergaard

Peter M Gordon

Affiliations

Soon will be listed here.

Abstract

Central nervous system (CNS) relapse is a significant cause of treatment failure among patients with acute lymphoblastic leukemia. In prior work we found that the meninges, the thin layer of tissue that covers the brain and spinal cord, harbor leukemia cells in the CNS. Importantly, direct interactions between leukemia and meningeal cells enabled leukemia chemoresistance. Herein, we show that an antibody targeting CD99, a transmembrane protein expressed on meningeal cells and many leukemia cells, disrupts adhesion between leukemia and meningeal cells and restores sensitivity of the leukemia cells to chemotherapy. This work identifies a mechanism regulating critical intercellular interactions within the CNS leukemia niche and may lead to novel therapeutic approaches for overcoming niche-mediated chemoresistance.

Citing Articles

Transcriptome Analysis Reveals the Induction of Apoptosis-Related Genes by a Monoclonal Antibody against a New Epitope of CD99 on T-Acute Lymphoblastic Leukemia.

Takheaw N, Kotemul K, Chaiwut R, Pata S, Laopajon W, Rangnoi K Antibodies (Basel). 2024; 13(2).

PMID: 38804310 PMC: 11130895. DOI: 10.3390/antib13020042.

CD99 tumor associated antigen is a potential target for antibody therapy of T-cell acute lymphoblastic leukemia.

Kotemul K, Kasinrerk W, Takheaw N Explor Target Antitumor Ther. 2024; 5(1):96-107.

PMID: 38468825 PMC: 10925484. DOI: 10.37349/etat.2024.00207.

Tissue Inhibitor of Metalloproteinases-1 Overexpression Mediates Chemoresistance in Triple-Negative Breast Cancer Cells.

Agnello L, dArgenio A, Caliendo A, Nilo R, Zannetti A, Fedele M Cells. 2023; 12(13).

PMID: 37443843 PMC: 10340747. DOI: 10.3390/cells12131809.

CXCR4 antagonists disrupt leukaemia-meningeal cell adhesion and attenuate chemoresistance.

Jonart L, Ostergaard J, Brooks A, Fitzpatrick G, Chen L, Gordon P Br J Haematol. 2022; 201(3):459-469.

PMID: 36535585 PMC: 10121760. DOI: 10.1111/bjh.18607.

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