Use of Hyaluronic Acid Associated with Triamcinolone Acetonide or Ozone Gas in the Treatment of Induced Osteoarthritis in Rabbits

Overview

Journal Acta Cir Bras

Specialty General Surgery

Date 2021 Dec 21

PMID 34932655

Authors

Giovanna Cristina Brombini

Sheila Canevese Rahal

Alexandre Todorovic Fabro

Ivan Felismino Charas Dos Santos

Miriam Harumi Tsunemi

Jean Guilherme Fernandes Joaquim

Danuta Pulz Doiche

Jeana Pereira da Silva

Maria Jaqueline Mamprim

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the effects of the intra-articular application of hyaluronic acid associated with triamcinolone acetonide, and ozone gas in the treatment of induced osteoarthritis in rabbit's stifles.

Methods: Twenty-one Norfolk rabbits were submitted to cranial cruciate ligament transection of the left stifle. After six weeks of the surgery, the rabbits were randomized assigned into three groups: G1 (control) - saline solution (0.9%); G2 - hyaluronic acid associated with triamcinolone; G3 - ozone gas, submitted to three intra-articular applications every seven days.

Results: Significant differences occurred: osteophytes at medial femoral condyle (G2 > G1, G2 > G3) on radiography exam; thickening of the medial condyle (G1 > G3, G2 > G3) on ultrasound exam; osteophytes at lateral tibial condyle (G2 > G1, G2 > G3), and medial femoral condyle (G1 > G2, G3 > G1) on computed tomography. Histologically, mean values of chondrocytes in the femur and tibia in G3 and G2 were statistically lower.

Conclusions: The intra-articular injection of hyaluronic acid associated with triamcinolone accentuated degenerative joint disease by imaging and macroscopic evaluations, and by histological findings, this treatment and the ozone gas treatment showed similar effects and were inferior to the saline solution (0.9%).

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