Sevoflurane Promotes Neurodegeneration Through Inflammasome Formation in APP/PS1 Mice

Overview

Journal Front Neurosci

Date 2021 Dec 20

PMID 34924922

Citations 2

Authors

Guohua Li

Yu Wang

Fang Cao

Dawei Wang

Limin Zhou

Yanwu Jin

Affiliations

Soon will be listed here.

Abstract

Sevoflurane (SEVO) is a highly fluorinated methyl isopropyl ether used as an inhalational anesthetic for general anesthesia. Previous studies have shown that SEVO may induce impaired memory and recognition ability and may be associated with neurodegenerative disease, e.g., Alzheimer's disease (AD). However, the underlying mechanism remains unknown. Here, we used a mouse AD model, APP/PS1, to study the effects of SEVO on neurodegeneration occurring in AD. We found that SEVO exposure significantly impaired the spatial reference memory, sensorimotor, and cognitive function of the mice. Mechanistically, we found that SEVO induced formation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream caspase 1-mediated production of IL-1β and IL-18, which subsequently deactivated brain-derived neurotrophic factor (BDNF) to promote neurodegeneration. Together, these data suggest that NLRP3 inflammasome is essential for SEVO-induced AD.

Citing Articles

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Yao J, Wang Z, Song W, Zhang Y Mol Psychiatry. 2023; 28(11):4512-4527.

PMID: 37670126 DOI: 10.1038/s41380-023-02239-0.

Minocycline Attenuates Sevoflurane-Induced Postoperative Cognitive Dysfunction in Aged Mice by Suppressing Hippocampal Apoptosis and the Notch Signaling Pathway-Mediated Neuroinflammation.

Liang J, Han S, Ye C, Zhu H, Wu J, Nie Y Brain Sci. 2023; 13(3).

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