Anti-idiotypes to Anti-Lolp I (Rye) Antibodies in Allergic and Non-allergic Individuals. Influence of Immunotherapy

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1986 Oct 1

PMID 3492316

Citations 6

Authors

R Bose

D G Marsh

G Delespesse

Affiliations

Soon will be listed here.

Abstract

Anti-idiotypes (aId) reacting with anti-Lol I (Lolp I; Rye I) antibodies were detected by their ability to bind to radioiodinated F(ab')2 anti-Lol I. Sera were tested after removal of anti-Lol I and anti-heavy and light chain activity by adsorption on Lol I-Sepharose 4B and normal human serum Sepharose 4B. The binding of aId to Id was inhibited by affinity purified anti-Lol I but not by certain unrelated immunoglobulins; in some sera this binding was also inhibited by Lol I. The levels of aId were measured in serial bleedings collected over a 1 year period from Lol I-sensitive patients, allergic donors not sensitive to Lol I and non-allergic persons. In Lol I-allergic patients the levels of aId were significantly influenced by seasonal exposure to pollen and by immunotherapy with extracts of grass pollen. Moreover, in 12 out of 16 cases, there was also a significant inverse relationship between changes in serum levels of aId and of IgG or IgE anti-Lol I. Most interestingly, aId were also detected in non-allergic individuals; in this case, the levels of aId were not influenced by the pollen season. The data suggest that Id-aId interactions may play a role in the regulation of anti-Lol I antibody production.

Citing Articles

Anti-ids in allergy: timeliness of a classic concept.

Wallmann J, Pali-Scholl I, Jensen-Jarolim E World Allergy Organ J. 2010; 3(6):195-201.

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Regulation of levels of serum antibodies to ryegrass pollen allergen Lol pIV by an internal image anti-idiotypic monoclonal antibody.

Zhou E, Kisil F Immunology. 1995; 84(3):343-9.

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Specific immunotherapy in house dust mite allergy.

Bousquet J, Des Roches A, Paradis L, Dhivert H, Michel F Clin Rev Allergy Immunol. 1995; 13(2):151-9.

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Human and murine antibodies to rye grass pollen allergen LolpIV share a common idiotope.

Bose R, Ekramoddoullah A, Kisil F, Sehon A Immunology. 1988; 63(4):579-84.

PMID: 2452788 PMC: 1454784.

Detection of auto-anti-idiotypic antibodies to Lol p I (rye I) IgE antibodies in human sera by the use of murine idiotypes: levels in atopic and non-atopic subjects and effects of immunotherapy.

Hebert J, Bernier D, Mourad W Clin Exp Immunol. 1990; 80(3):413-9.

PMID: 2372990 PMC: 1535190. DOI: 10.1111/j.1365-2249.1990.tb03303.x.

References

Marsh D, MILNER F, Johnson P . The allergenic activity and stability of purified allergens from the pollen of common rye grass (lolium perenne). Int Arch Allergy Appl Immunol. 1966; 29(6):521-35. DOI: 10.1159/000229739. View

Bose R, Marsh D, Duchateau J, Sehon A, Delespesse G . Demonstration of auto-anti-idiotypic antibody cross-reacting with public idiotypic determinants in the serum of rye-sensitive allergic patients. J Immunol. 1984; 133(5):2474-8. View

Klinman N, Taylor R . General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice. Clin Exp Immunol. 1969; 4(4):473-87. PMC: 1579022. View

OUDIN J, Cazenave P . Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function. Proc Natl Acad Sci U S A. 1971; 68(10):2616-20. PMC: 389480. DOI: 10.1073/pnas.68.10.2616. View

Jerne N . Towards a network theory of the immune system. Ann Immunol (Paris). 1974; 125C(1-2):373-89. View

Bankert R, Pressman D . Receptor-blocking factor present in immune serum resembling auto-anti-idiotype antibody. J Immunol. 1976; 117(2):457-62. View

Platts-Mills T . Local production of IgG, IgA and IgE antibodies in grass pollen hay fever. J Immunol. 1979; 122(6):2218-25. View

Schrater A, Goidl E, Thorbecke G, Siskind G . Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen.... J Exp Med. 1979; 150(1):138-53. PMC: 2185608. DOI: 10.1084/jem.150.1.138. View

Kelsoe G, cerny J . Reciprocal expansions of idiotypic and anti-idiotypic clones following antigen stimulation. Nature. 1979; 279(5711):333-4. DOI: 10.1038/279333a0. View

10.

Forni L, Coutinho A, Kohler G, Jerne N . IgM antibodies induce the production of antibodies of the same specificity. Proc Natl Acad Sci U S A. 1980; 77(2):1125-8. PMC: 348437. DOI: 10.1073/pnas.77.2.1125. View

11.

Geltner D, FRANKLIN E, Frangione B . Antiidiotypic activity in the IgM fractions of mixed cryoglobulins. J Immunol. 1980; 125(4):1530-5. View

12.

Reth M, Kelsoe G, Rajewsky K . Idiotypic regulation by isologous monoclonal anti-idiotope antibodies. Nature. 1981; 290(5803):257-9. DOI: 10.1038/290257a0. View

13.

Abdou N, Wall H, Lindsley H, Halsey J, Suzuki T . Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus. J Clin Invest. 1981; 67(5):1297-304. PMC: 370696. DOI: 10.1172/jci110158. View

14.

Marsh D, Hsu S, Roebber M, Freidhoff L, Meyers D, Pollard M . HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure. J Exp Med. 1982; 155(5):1439-51. PMC: 2186667. DOI: 10.1084/jem.155.5.1439. View

15.

Geha R . Presence of auto-anti-idiotypic antibody during the normal human immune response to tetanus toxoid antigen. J Immunol. 1982; 129(1):139-44. View

16.

Gleich G, Zimmermann E, HENDERSON L, Yunginger J . Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study. J Allergy Clin Immunol. 1982; 70(4):261-71. DOI: 10.1016/0091-6749(82)90062-8. View

17.

Blaser K, de Weck A . Regulation of the IgE antibody response by idiotype-anti-idiotype network. Prog Allergy. 1982; 32:203-64. View

18.

Dwyer D, Bradley R, Urquhart C, Kearney J . Naturally occurring anti-idiotypic antibodies in myasthenia gravis patients. Nature. 1983; 301(5901):611-4. DOI: 10.1038/301611a0. View

19.

Saxon A, Barnett E . Human auto-antiidiotypes regulating T cell-mediated reactivity to tetanus toxoid. J Clin Invest. 1984; 73(2):342-8. PMC: 425023. DOI: 10.1172/JCI111218. View

20.

Axen R, Porath J, Ernback S . Chemical coupling of peptides and proteins to polysaccharides by means of cyanogen halides. Nature. 1967; 214(5095):1302-4. DOI: 10.1038/2141302a0. View