NIH Policies and Regulatory Pathways for the Advancement of Radiation Medical Countermeasures and Biodosimetry Tools to U.S. FDA Licensure

Overview

Journal Radiat Res

Specialties Genetics
Radiology

Date 2021 Dec 17

PMID 34919721

Citations 1

Authors

Lanyn P Taliaferro

Andrea L DiCarlo

Merriline M Satyamitra

Affiliations

Soon will be listed here.

Citing Articles

An Overview of Radiation Countermeasure Development in Radiation Research from 1954 to 2024.

Kiang J, Cannon G, Singh V Radiat Res. 2024; 202(2):420-431.

PMID: 38964743 PMC: 11385179. DOI: 10.1667/RADE-24-00036.1.

References

Farese A, Cohen M, Katz B, Smith C, Gibbs A, Cohen D . Filgrastim improves survival in lethally irradiated nonhuman primates. Radiat Res. 2012; 179(1):89-100. PMC: 4562422. DOI: 10.1667/RR3049.1. View

Royba E, Repin M, Balajee A, Shuryak I, Pampou S, Karan C . The RABiT-II DCA in the Rhesus Macaque Model. Radiat Res. 2020; 196(5):501-509. PMC: 9039759. DOI: 10.1667/RR15547.1. View

Rios C, Cassatt D, DiCarlo A, Macchiarini F, Ramakrishnan N, Norman M . Building the strategic national stockpile through the NIAID Radiation Nuclear Countermeasures Program. Drug Dev Res. 2014; 75(1):23-8. PMC: 8365557. DOI: 10.1002/ddr.21163. View

Parker G, Li N, Takayama K, Farese A, MacVittie T . Lung and Heart Injury in a Nonhuman Primate Model of Partial-body Irradiation with Minimal Bone Marrow Sparing: Histopathological Evidence of Lung and Heart Injury. Health Phys. 2019; 116(3):383-400. PMC: 6381599. DOI: 10.1097/HP.0000000000000936. View

Moulder J, Fish B . Late toxicity of total body irradiation with bone marrow transplantation in a rat model. Int J Radiat Oncol Biol Phys. 1989; 16(6):1501-9. DOI: 10.1016/0360-3016(89)90955-3. View

Booth C, Tudor G, Tudor J, Katz B, MacVittie T . Acute gastrointestinal syndrome in high-dose irradiated mice. Health Phys. 2012; 103(4):383-99. PMC: 3530834. DOI: 10.1097/hp.0b013e318266ee13. View

Bensimon Etzol J, Valente M, Altmeyer S, Bettencourt C, Bouvet S, Cosler G . DosiKit, a New Portable Immunoassay for Fast External Irradiation Biodosimetry. Radiat Res. 2017; 190(2):176-185. DOI: 10.1667/RR14760.1. View

Booth C, Tudor G, Tonge N, Shea-Donohue T, MacVittie T . Evidence of delayed gastrointestinal syndrome in high-dose irradiated mice. Health Phys. 2012; 103(4):400-10. PMC: 3551349. DOI: 10.1097/hp.0b013e31826530e2. View

Jackson I, Vujaskovic Z, Down J . A further comparison of pathologies after thoracic irradiation among different mouse strains: finding the best preclinical model for evaluating therapies directed against radiation-induced lung damage. Radiat Res. 2011; 175(4):510-18. PMC: 3110676. DOI: 10.1667/RR2421.1. View

10.

Wong K, Chang P, Fielden M, Downey A, Bunin D, Bakke J . Pharmacodynamics of romiplostim alone and in combination with pegfilgrastim on acute radiation-induced thrombocytopenia and neutropenia in non-human primates. Int J Radiat Biol. 2019; 96(1):155-166. DOI: 10.1080/09553002.2019.1625488. View

11.

Case Jr C . Radiation Injury Treatment Network®: Preparedness Through a Coalition of Cancer Centers. Health Phys. 2016; 111(2):145-8. DOI: 10.1097/HP.0000000000000439. View

12.

Garofalo M, Bennett A, Farese A, Harper J, Ward A, Taylor-Howell C . The delayed pulmonary syndrome following acute high-dose irradiation: a rhesus macaque model. Health Phys. 2013; 106(1):56-72. DOI: 10.1097/HP.0b013e3182a32b3f. View

13.

Cohen E, Hankey K, Bennett A, Farese A, Parker G, MacVittie T . Acute and Chronic Kidney Injury in a Non-Human Primate Model of Partial-Body Irradiation with Bone Marrow Sparing. Radiat Res. 2017; 188(6):661-671. PMC: 7737227. DOI: 10.1667/RR24857.1. View

14.

Laiakis E, Nishita D, Bujold K, Jayatilake M, Bakke J, Gahagen J . Salivary Metabolomics of Total Body Irradiated Nonhuman Primates Reveals Long-Term Normal Tissue Responses to Radiation. Int J Radiat Oncol Biol Phys. 2019; 105(4):843-851. PMC: 6815709. DOI: 10.1016/j.ijrobp.2019.07.017. View

15.

Kaur A, Ten Have G, Hritzo B, Deutz N, Olsen C, Moroni M . Morphological and functional impairment in the gut in a partial body irradiation minipig model of GI-ARS. Int J Radiat Biol. 2018; 96(1):112-128. DOI: 10.1080/09553002.2018.1552377. View

16.

Bunin D, Bakke J, Green C, Javitz H, Fielden M, Chang P . Romiplostim (Nplate) as an effective radiation countermeasure to improve survival and platelet recovery in mice. Int J Radiat Biol. 2019; 96(1):145-154. DOI: 10.1080/09553002.2019.1605465. View

17.

Huckle J, Sadgrove M, Pacyniak E, Leed M, Weber W, Doyle-Eisele M . Orally administered DTPA di-ethyl ester for decorporation of (241)Am in dogs: Assessment of safety and efficacy in an inhalation-contamination model. Int J Radiat Biol. 2015; 91(7):568-75. PMC: 4733509. DOI: 10.3109/09553002.2015.1043753. View

18.

Pannkuk E, Laiakis E, Girgis M, Dowd S, Dhungana S, Nishita D . Temporal Effects on Radiation Responses in Nonhuman Primates: Identification of Biofluid Small Molecule Signatures by Gas Chromatography⁻Mass Spectrometry Metabolomics. Metabolites. 2019; 9(5). PMC: 6571779. DOI: 10.3390/metabo9050098. View

19.

Weber W, Doyle-Eisele M, Melo D, Guilmette R . Whole-body distribution of plutonium in rats for different routes of exposure. Int J Radiat Biol. 2014; 90(11):1011-8. DOI: 10.3109/09553002.2014.894651. View

20.

MacVittie T, Farese A, Kane M . ARS, DEARE, and Multiple-organ Injury: A Strategic and Tactical Approach to Link Radiation Effects, Animal Models, Medical Countermeasures, and Biomarker Development to Predict Clinical Outcome. Health Phys. 2019; 116(4):453. PMC: 7472511. DOI: 10.1097/HP.0000000000001050. View