ExoRBase 2.0: an Atlas of MRNA, LncRNA and CircRNA in Extracellular Vesicles from Human Biofluids

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2021 Dec 17

PMID 34918744

Citations 84

Authors

Hongyan Lai

Yuchen Li

Hena Zhang

Jia Hu

Jiatao Liao

Ying Su

Qin Li

Bing Chen

Caiping Li

Zhen Wang

Yan Li

Jialei Wang

Zhiqiang Meng

Zhaohui Huang

Shenglin Huang

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) are small membranous vesicles that contain an abundant cargo of different RNA species with specialized functions and clinical implications. Here, we introduce an updated online database (http://www.exoRBase.org), exoRBase 2.0, which is a repository of EV long RNAs (termed exLRs) derived from RNA-seq data analyses of diverse human body fluids. In exoRBase 2.0, the number of exLRs has increased to 19 643 messenger RNAs (mRNAs), 15 645 long non-coding RNAs (lncRNAs) and 79 084 circular RNAs (circRNAs) obtained from ∼1000 human blood, urine, cerebrospinal fluid (CSF) and bile samples. Importantly, exoRBase 2.0 not only integrates and compares exLR expression profiles but also visualizes the pathway-level functional changes and the heterogeneity of origins of circulating EVs in the context of different physiological and pathological conditions. Our database provides an attractive platform for the identification of novel exLR signatures from human biofluids that will aid in the discovery of new circulating biomarkers to improve disease diagnosis and therapy.

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