Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Dec 17

PMID 34917512

Citations 8

Authors

Pierre Loap

Barbara Vischioni

Maria Bonora

Rossana Ingargiola

Sara Ronchi

Viviana Vitolo

Amelia Barcellini

Lucia Goanta

Ludovic De Marzi

Remi Dendale

Roberto Pacelli

Laura Locati

Valentin Calugaru

Hamid Mammar

Stefano Cavalieri

Youlia Kirova

Ester Orlandi

Affiliations

Soon will be listed here.

Abstract

Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams used for hadron therapy. Carbon ion radiation therapy (CIRT) is currently increasingly used for ACC irradiation. The aim of this review is to describe the immunological, molecular and clinicopathological bases that support ACC treatment with CIRT, as well as to expose the current clinical evidence that reveal the advantages of using CIRT for treating ACC.

Citing Articles

Current landscape and future directions of therapeutic approaches for adenoid cystic carcinoma of the salivary glands (Review).

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