Immunological Investigations in Individuals with Selective IgA Deficiency

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1986 Jun 1

PMID 3491694

Citations 4

Authors

T A Out

P J VAN MUNSTER

P A de Graeff

T H The

J M Vossen

B J Zegers

Affiliations

Soon will be listed here.

Abstract

Concentrations of IgG2, IgG4 and IgE were low in 16, 24 and 20% of 25 persons with selective IgA deficiency. Fifty-two per cent had IgD concentrations below 5 iu/ml. Trends for association between any of these parameters and the presence of clinical symptoms were not significant. All patients, except one, had normal amounts of Ig-bearing lymphocytes in the blood. IgG1 antibodies against casein were increased in titre and frequency, whereas IgG4 antibodies were normal. Similar results were found in other sera from persons with selective IgA deficiency.

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References

Brandtzaeg P, Fjellanger I, GJERULDSEN S . Immunoglobulin M: local synthesis and selective secretion in patients with immunoglobulin A deficiency. Science. 1968; 160(3829):789-91. DOI: 10.1126/science.160.3829.789. View

Laschinger C, Gauthier D, Valet J, Naylor D . Fluctuating levels of serum IgA in individuals with selective IgA deficiency. Vox Sang. 1984; 47(1):60-7. DOI: 10.1111/j.1423-0410.1984.tb01562.x. View

Ammann A, Hong R . Selective IgA deficiency: presentation of 30 cases and a review of the literature. Medicine (Baltimore). 1971; 50(3):223-36. View

POLMAR S, Waldmann T, Balestra S, Jost M, TERRY W . Immunoglobulin E in immunologic deficiency diseases. I. Relation of IgE and IgA to respiratory tract disease in isolated IgE deficiency, IgA deficiency, and ataxia telangiectasia. J Clin Invest. 1972; 51(2):326-30. PMC: 302130. DOI: 10.1172/JCI106817. View

Jondal M, Holm G, Wigzell H . Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972; 136(2):207-15. PMC: 2139198. DOI: 10.1084/jem.136.2.207. View

Nadorp J, Voss M, Buys W, VAN MUNSTER P, van Tongeren J, Aalberse R . The significance of the presence of anti-IgA antibodies in individuals with an IgA deficiency. Eur J Clin Invest. 1973; 3(4):317-23. DOI: 10.1111/j.1365-2362.1973.tb00357.x. View

Buckley R, Fiscus S . Serum IgD and IgE concentrations in immunodeficiency diseases. J Clin Invest. 1975; 55(1):157-65. PMC: 301727. DOI: 10.1172/JCI107906. View

Buckley R . Clinical and immunologic features of selective IgA deficiency. Birth Defects Orig Artic Ser. 1975; 11(1):134-42. View

Vossen J . Membrane-associated immunoglobulin determinants on bone marrow and blood lymphocytes in the pediatric age group and on fetal tissues. Ann N Y Acad Sci. 1975; 254:262-79. DOI: 10.1111/j.1749-6632.1975.tb29176.x. View

10.

Aarden L, de Groot E, FELTKAMP T . Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann N Y Acad Sci. 1975; 254:505-15. DOI: 10.1111/j.1749-6632.1975.tb29197.x. View

11.

Humphrey J, Batty I . International reference preparation for human serum IgG, IgA, IgM. Clin Exp Immunol. 1974; 17(4):708. PMC: 1554098. View

12.

Zegers B, Stoop J, REERINK-BRONGERS E, Sander P, Aalberse R, Ballieux R . Serum immunoglobulins in healthy children and adults. Levels of the five classes, expressed in international units per millilitre. Clin Chim Acta. 1975; 65(3):319-29. DOI: 10.1016/0009-8981(75)90257-0. View

13.

VAN DER GIESSEN M, Rossouw E, van Veen T, van Loghem E, Zegers B, Sander P . Quantification of IgG subclasses in sera of normal adults and healthy children between 4 and 12 years of age. Clin Exp Immunol. 1975; 21(3):501-9. PMC: 1538307. View

14.

VAN DER GIESSEN M, REERINK-BRONGERS E, Veen T . Quantitation of Ig classes and IgG subclasses in sera of patients with a variety of immunoglobulin deficiencies and their relatives. Clin Immunol Immunopathol. 1976; 5(3):388-98. DOI: 10.1016/0090-1229(76)90048-9. View

15.

Stallman P, Aalberse R . Estimation of basophil-bound IgE by quantitative immunofluorescence microscopy. Int Arch Allergy Appl Immunol. 1977; 54(1):9-18. DOI: 10.1159/000231803. View

16.

Walker W, Isselbacher K . Intestinal antibodies. N Engl J Med. 1977; 297(14):767-73. DOI: 10.1056/NEJM197710062971407. View

17.

Dunnette S, Gleich G, Miller R, Kyle R . Measurement of IgD by a double antibody radioimmunoassay: demonstration of an apparent trimodal distribution of IgD levels in normal human sera. J Immunol. 1977; 119(5):1727-31. View

18.

VAN MUNSTER P, Nadorp J, Schuurman H . Human antibodies to immunoglobulin A (IgA). A radioimmunological method for differentiation between anti-IgA antibodies and IgA in the serum of IgA deficient individuals. J Immunol Methods. 1978; 22(3-4):233-45. DOI: 10.1016/0022-1759(78)90031-5. View

19.

Cunningham-Rundles C, Brandeis W, GOOD R, Day N . Milk precipitins, circulating immune complexes, and IgA deficiency. Proc Natl Acad Sci U S A. 1978; 75(7):3387-9. PMC: 392781. DOI: 10.1073/pnas.75.7.3387. View

20.

Barrett D, Bertani L, Wara D, Ammann A . Milk precipitins in selective IgA deficiency. Ann Allergy. 1979; 42(2):73-6. View