Neopterin Production in Inflamed Knee Joints: High Levels in Synovial Fluids

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 1986 Jan 1

PMID 3491410

Citations 4

Authors

O Diemer

R Strumper

M Rohe

Affiliations

Soon will be listed here.

Abstract

Neopterin levels of serum and fluid were determined in 30 patients with inflammatory synovial fluids and in 30 controls with joint effusions induced by trauma or osteoarthritis. Neopterin was significantly elevated in inflammatory fluids. There was no correlation with the acute phase reactants. Neopterin levels were significantly higher in inflammatory fluids than in serum, and vice versa in non-inflammatory conditions. Our results indicate that in arthritis neopterin is produced locally in the joint by monocytes induced by T-cell activation.

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References

Huber C, Batchelor J, Fuchs D, Hausen A, Lang A, Niederwieser D . Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J Exp Med. 1984; 160(1):310-6. PMC: 2187425. DOI: 10.1084/jem.160.1.310. View

Kaufman S . THE STRUCTURE OF THE PHENYLALANINE-HYDROXYLATION COFACTOR. Proc Natl Acad Sci U S A. 1963; 50:1085-93. PMC: 221278. DOI: 10.1073/pnas.50.6.1085. View

Hausen A, Fuchs D, Grunewald K, HUBER H, Konig K, Wachter H . Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy. Clin Biochem. 1982; 15(1):34-7. DOI: 10.1016/s0009-9120(82)90403-9. View

Fuchs D, Hausen A, Huber C, Margreiter R, Reibnegger G, Spielberger M . [Pteridine secretion as a marker for the proliferation of alloantigen-induced lymphocytes (author's transl)]. Hoppe Seylers Z Physiol Chem. 1982; 363(6):661-4. View

Mancini G, Carbonara A, Heremans J . Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965; 2(3):235-54. DOI: 10.1016/0019-2791(65)90004-2. View

Hausen A, Fuchs D, Grunewald K, HUBER H, Konig K, Wachter H . Urinary neopterine as marker for haematological neoplasias. Clin Chim Acta. 1981; 117(3):297-305. DOI: 10.1016/0009-8981(81)90117-0. View

Wachter H, Fuchs D, Hausen A, Huber C, Knosp O, Reibnegger G . Elevated urinary neopterin levels in patients with the acquired immunodeficiency syndrome (AIDS). A preliminary report. Hoppe Seylers Z Physiol Chem. 1983; 364(9):1345-6. DOI: 10.1515/bchm2.1983.364.2.1345. View

Bichler A, Fuchs D, Hausen A, HETZEL H, Reibnegger G, Wachter H . Measurement of urinary neopterin in normal pregnant and non-pregnant women and in women with benign and malignant genital tract neoplasms. Arch Gynecol. 1983; 233(2):121-30. DOI: 10.1007/BF02114788. View

Levick J . Permeability of rheumatoid and normal human synovium to specific plasma proteins. Arthritis Rheum. 1981; 24(12):1550-60. DOI: 10.1002/art.1780241215. View

10.

Wachter H, Hausen A, Grassmayr K . [Increased urinary excretion of neopterin in patients with malignant tumors and with virus diseases (author's transl)]. Hoppe Seylers Z Physiol Chem. 1979; 360(12):1957-60. View

11.

Reibnegger G, Boonpucknavig V, Fuchs D, Hausen A, Schmutzhard E, Wachter H . Urinary neopterin is elevated in patients with malaria. Trans R Soc Trop Med Hyg. 1984; 78(4):545-6. DOI: 10.1016/0035-9203(84)90080-4. View

12.

Ziegler I, Hamm U, Berndt J . Participation of pterins in the control of lymphocyte stimulation and lymphoblast proliferation. Cancer Res. 1983; 43(11):5356-9. View

13.

Huber C, Fuchs D, Hausen A, Margreiter R, Reibnegger G, Spielberger M . Pteridines as a new marker to detect human T cells activated by allogeneic or modified self major histocompatibility complex (MHC) determinants. J Immunol. 1983; 130(3):1047-50. View