Hepatoprotective Screening of (Qazilb.) Y.R. Ling

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2021 Dec 16

PMID 34912897

Citations 1

Authors

Maroof Ali

Hidayat Hussain

Amjad Hussain

Abdur Rauf

Wahid Hussain

Manzoor Ullah

Safdar Abbas

Yahya S Al-Awthan

Omar Bahattab

Muhammad Khan

Ahmed Olatunde

Zainab M Almarhoon

Yahia N Mabkhot

Mohammed M Alshehri

Sevgi Durna Dastan

Mohamed Fawzy Ramadan

Javad Sharifi-Rad

Affiliations

Soon will be listed here.

Abstract

Investigation on medicinal plants' therapeutic potential has gained substantial importance in the discovery of novel effective and safe therapeutic agents. The present study is aimed at investigating the hepatoprotective potential of methanolic extract (SKM) against carbon tetrachloride- (CCl-) induced hepatotoxicity in rats. is one of the most imperative plants for its various pharmacological activities. Therefore, this study was aimed at evaluating the hepatoprotective potential against CCl-induced liver toxicity. The serum samples were analyzed for alanine aminotransferase (ALT) and aspartate aminotransferase (AST) together with the oxidative stress mediator levels as nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), reduced glutathione (GSH), and superoxide dismutase (SOD) as well as peroxidation and HO activity. CCl administration resulted in an elevated free radical generation, altered liver marker (AST and ALT) enzymes, reduced antioxidant enzyme, and increased DNA damage. Methanolic extract of decreased CCl-induced hepatotoxicity by increasing the antioxidant status and reducing HO and nitrate content generation as well as reducing DNA damage. Additionally, SKM reversed the morphological alterations induced by CCl in the SKM-treated groups. These results demonstrated that SKM displayed hepatoprotective activity against CCl-induced hepatic damage in experimental rats.

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References

Ozturk I, Altinbas M, Koyuncu I, Arikan O, Gomec-Yangin C . Advanced physico-chemical treatment experiences on young municipal landfill leachates. Waste Manag. 2003; 23(5):441-6. DOI: 10.1016/S0956-053X(03)00061-8. View

Jacob R, Sotoudeh G . Vitamin C function and status in chronic disease. Nutr Clin Care. 2002; 5(2):66-74. DOI: 10.1046/j.1523-5408.2002.00005.x. View

Das S, Vasudevan D . Alcohol-induced oxidative stress. Life Sci. 2007; 81(3):177-87. DOI: 10.1016/j.lfs.2007.05.005. View

Ali M, Bahadur S, Hussain A, Saeed S, Khuram I, Ullah M . Foliar epidermal micromorphology and its taxonomic significance in Polygonatum (Asparagaceae) using scanning electron microscopy. Microsc Res Tech. 2020; 83(11):1381-1390. DOI: 10.1002/jemt.23529. View

Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C . Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 2001; 29(4):365-71. DOI: 10.1038/ng1201-365. View

Shyu M, Kao T, Yen G . Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl(4) via inhibition of hepatic stellate cells activation. Food Chem Toxicol. 2008; 46(12):3707-13. DOI: 10.1016/j.fct.2008.09.051. View

Basu S . Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology. 2003; 189(1-2):113-27. DOI: 10.1016/s0300-483x(03)00157-4. View

Grisham M, Johnson G, Lancaster Jr J . Quantitation of nitrate and nitrite in extracellular fluids. Methods Enzymol. 1996; 268:237-46. DOI: 10.1016/s0076-6879(96)68026-4. View

MAEHLY A, Chance B . The assay of catalases and peroxidases. Methods Biochem Anal. 1954; 1:357-424. DOI: 10.1002/9780470110171.ch14. View

10.

Saller R, Brignoli R, Melzer J, Meier R . An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementmed. 2008; 15(1):9-20. DOI: 10.1159/000113648. View

11.

Zhang X, Xie X, Wang H, Zhang J, Pan B, Xie Y . Enhanced photoresponsive ultrathin graphitic-phase C3N4 nanosheets for bioimaging. J Am Chem Soc. 2012; 135(1):18-21. DOI: 10.1021/ja308249k. View

12.

Xiao L, Shi Z, Xu F, Sun R . Hydrothermal carbonization of lignocellulosic biomass. Bioresour Technol. 2012; 118:619-23. DOI: 10.1016/j.biortech.2012.05.060. View

13.

Weber G, Heilborn J, Chamorro Jimenez C, Hammarsjo A, Torma H, Stahle M . Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Invest Dermatol. 2005; 124(5):1080-2. DOI: 10.1111/j.0022-202X.2005.23687.x. View

14.

Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M . Autophagy regulates lipid metabolism. Nature. 2009; 458(7242):1131-5. PMC: 2676208. DOI: 10.1038/nature07976. View

15.

Ferenci P, Dragosics B, DITTRICH H, Frank H, BENDA L, Lochs H . Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol. 1989; 9(1):105-13. DOI: 10.1016/0168-8278(89)90083-4. View

16.

Sadasivan S, Latha P, Sasikumar J, Rajashekaran S, Shyamal S, Shine V . Hepatoprotective studies on Hedyotis corymbosa (L.) Lam. J Ethnopharmacol. 2006; 106(2):245-9. DOI: 10.1016/j.jep.2006.01.002. View

17.

Kus B, Caldon C, Andorn-Broza R, Edwards A . Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro. Proteins. 2004; 54(3):455-67. DOI: 10.1002/prot.10620. View

18.

Hussain W, Badshah L, Ullah M, Ali M, Ali A, Hussain F . Quantitative study of medicinal plants used by the communities residing in Koh-e-Safaid Range, northern Pakistani-Afghan borders. J Ethnobiol Ethnomed. 2018; 14(1):30. PMC: 5922303. DOI: 10.1186/s13002-018-0229-4. View

19.

Janbaz K, Gilani A . Evaluation of the protective potential of Artemisia maritima extract on acetaminophen- and CCl4-induced liver damage. J Ethnopharmacol. 1995; 47(1):43-7. DOI: 10.1016/0378-8741(95)01252-9. View

20.

Abraham P, Wilfred G, Cathrine . Oxidative damage to the lipids and proteins pf the lungs, testis and kidney of rats during carbon tetrachloride intoxication. Clin Chim Acta. 2000; 289(1-2):177-9. DOI: 10.1016/s0009-8981(99)00140-0. View