Incidence and Risk Factors of Dry Eye in Children and Adolescents With Diabetes Mellitus: A 3-Year Follow-Up Study

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2021 Dec 16

PMID 34912822

Citations 7

Authors

Zhangling Chen

Ying Xiao

Yu Qian

Qiurong Lin

Zhaoyu Xiang

Lipu Cui

Jiaqi Sun

Sicong Li

Xinran Qin

Chenhao Yang

Haidong Zou

Affiliations

Soon will be listed here.

Abstract

To investigate the incidence and risk factors of dry eye in children with diabetes mellitus (DM) over a period of 3 years. Children and adolescents with DM (age: 3-14 years) from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study cohort who did not have dry eye in January 2018 were followed-up for 3 years and re-examined in January 2021, and the incidence rate and risk factors for dry eye were calculated. Forty children and adolescents with DM came for follow-up in 2021. Nine of them were diagnosed with dry eye, resulting in a 3-year incidence rate of 22.5% and an annual mean incidence rate of 7.5% for dry eye. Univariate regression analysis confirmed that decreased corneal sensation (OR [Odds Ratio] = 25.60; 95%CI [Confidence Interval] = 1.31~501.69; = 0.03) was the risk factor for dry eye incidence. Long course of DM (OR = 1.80; 95%CI = 0.96~3.38; = 0.07), eye pain (OR = 12.27; 95%CI = 0.65~231.48; = 0.09), and dry eye in parents (OR = 15.99; 95%CI = 0.76~337.75; = 0.08) may interfere with the incidence of dry eye in them. The incidence of dry eye in children and adolescents with DM is high.

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