The Role of Gut Microbiota and Genetic Susceptibility in the Pathogenesis of Pancreatitis

Overview

Journal Gut Liver

Specialty Gastroenterology

Date 2021 Dec 15

PMID 34911043

Citations 6

Authors

Fumin Xu

Chunmei Yang

Mingcheng Tang

Ming Wang

Zhenhao Cheng

Dongfeng Chen

Xiao Chen

Kaijun Liu

Affiliations

Soon will be listed here.

Abstract

Pancreatitis is one of the most common inflammatory diseases of the pancreas caused by autodigestion induced by excessive premature protease activation. However, recognition of novel pathophysiological mechanisms remains a still challenge. Both genetic and environmental factors contribute to the pathogenesis of pancreatitis, and the gut microbiota is a potential source of an environmental effect. In recent years, several new frontiers in gut microbiota and genetic risk assessment research have emerged and improved the understanding of the disease. These investigations showed that the disease progression of pancreatitis could be regulated by the gut microbiome, either through a translocation influence or in a host immune response manner. Meanwhile, the onset of the disease is also associated with the heritage of a pathogenic mutation, and the disease progression could be modified by genetic risk factors. In this review, we focused on the recent advances in the role of gut microbiota in the pathogenesis of pancreatitis, and the genetic susceptibility in pancreatitis.

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References

Chen J, Ferec C . Genetics and pathogenesis of chronic pancreatitis: the 2012 update. Clin Res Hepatol Gastroenterol. 2012; 36(4):334-40. DOI: 10.1016/j.clinre.2012.05.003. View

Schneider A, Pfutzer R, Barmada M, Slivka A, Martin J, Whitcomb D . Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States. Dig Dis Sci. 2003; 48(6):1110-5. DOI: 10.1023/a:1023768829772. View

Rosendahl J, Landt O, Bernadova J, Kovacs P, Teich N, Bodeker H . CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?. Gut. 2012; 62(4):582-92. DOI: 10.1136/gutjnl-2011-300645. View

Akshintala V, Talukdar R, Singh V, Goggins M . The Gut Microbiome in Pancreatic Disease. Clin Gastroenterol Hepatol. 2018; 17(2):290-295. PMC: 6314887. DOI: 10.1016/j.cgh.2018.08.045. View

Bures J, Cyrany J, Kohoutova D, Forstl M, Rejchrt S, Kvetina J . Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010; 16(24):2978-90. PMC: 2890937. DOI: 10.3748/wjg.v16.i24.2978. View

Hamada S, Masamune A, Nabeshima T, Shimosegawa T . Differences in Gut Microbiota Profiles between Autoimmune Pancreatitis and Chronic Pancreatitis. Tohoku J Exp Med. 2018; 244(2):113-117. DOI: 10.1620/tjem.244.113. View

Zhang X, Zhang Z, Zhang C, Wu J, Wang Y, Zhang G . Intestinal Microbial Community Differs between Acute Pancreatitis Patients and Healthy Volunteers. Biomed Environ Sci. 2018; 31(1):81-86. DOI: 10.3967/bes2018.010. View

Yu S, Xiong Y, Xu J, Liang X, Fu Y, Liu D . Identification of Dysfunctional Gut Microbiota Through Rectal Swab in Patients with Different Severity of Acute Pancreatitis. Dig Dis Sci. 2020; 65(11):3223-3237. DOI: 10.1007/s10620-020-06061-4. View

Olah A, Belagyi T, Poto L, Romics Jr L, Bengmark S . Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study. Hepatogastroenterology. 2007; 54(74):590-4. View

10.

Pushalkar S, Hundeyin M, Daley D, Zambirinis C, Kurz E, Mishra A . The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. Cancer Discov. 2018; 8(4):403-416. PMC: 6225783. DOI: 10.1158/2159-8290.CD-17-1134. View

11.

Besselink M, van Santvoort H, Buskens E, Boermeester M, Goor H, Timmerman H . Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008; 371(9613):651-659. DOI: 10.1016/S0140-6736(08)60207-X. View

12.

Wang W, Xiao Y, Wang X, Zhou Y, Wang T, Xv C . Disordered Gut Microbiota in Children Who Have Chronic Pancreatitis and Different Functional Gene Mutations. Clin Transl Gastroenterol. 2020; 11(3):e00150. PMC: 7145041. DOI: 10.14309/ctg.0000000000000150. View

13.

Whitcomb D, LaRusch J, Krasinskas A, Klei L, Smith J, Brand R . Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012; 44(12):1349-54. PMC: 3510344. DOI: 10.1038/ng.2466. View

14.

Russell J, Roesch L, Ordberg M, Ilonen J, Atkinson M, Schatz D . Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome. Nat Commun. 2019; 10(1):3621. PMC: 6689114. DOI: 10.1038/s41467-019-11460-x. View

15.

Whitcomb D . Mechanisms of disease: Advances in understanding the mechanisms leading to chronic pancreatitis. Nat Clin Pract Gastroenterol Hepatol. 2005; 1(1):46-52. DOI: 10.1038/ncpgasthep0025. View

16.

Banks P, Bollen T, Dervenis C, Gooszen H, Johnson C, Sarr M . Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2012; 62(1):102-11. DOI: 10.1136/gutjnl-2012-302779. View

17.

Keller J, Layer P . Idiopathic chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2008; 22(1):105-13. DOI: 10.1016/j.bpg.2007.10.006. View

18.

Lugea A, Waldron R, Mareninova O, Shalbueva N, Deng N, Su H . Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis. Am J Pathol. 2017; 187(12):2726-2743. PMC: 5718097. DOI: 10.1016/j.ajpath.2017.08.017. View

19.

Cui L, Wang X, Peng L, Yu L, Yang Y . [The effects of early enteral nutrition with addition of probiotics on the prognosis of patients suffering from severe acute pancreatitis]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2013; 25(4):224-8. DOI: 10.3760/cma.j.issn.2095-4352.2013.04.011. View

20.

Lee P, Papachristou G . New insights into acute pancreatitis. Nat Rev Gastroenterol Hepatol. 2019; 16(8):479-496. DOI: 10.1038/s41575-019-0158-2. View