Effect of Selenium-Enriched Yeast Supplementation on Serum Thyroid-Stimulating Hormone and Anti-Thyroid Peroxidase Antibody Levels in Subclinical Hypothyroidism: Randomized Controlled Trial

Overview

Journal Adv Biomed Res

Specialty Biomedical Engineering

Date 2021 Dec 15

PMID 34909430

Citations 5

Authors

Leila Mahmoudi

Majid Mobasseri

Alireza Ostadrahimi

Samira Pourmoradian

Hamid Soleimanzadeh

Behnam Kafili

Affiliations

Soon will be listed here.

Abstract

Background: In the subclinical hypothyroidism, T4 or T3 levels are normal and thyroid-stimulating hormone (TSH) is slightly high. Selenium deficiency can lead to thyroid dysfunction. The present study aims to investigate the effect of selenium supplementation on the thyroid hormone and anti-thyroid peroxidase antibody (anti-TPO AB) levels.

Materials And Methods: In this double-blinded, randomized, placebo-controlled clinical trial, 42 patients with subclinical hypothyroidism were randomly assigned to receive 200 μg selenium or placebo for 8 weeks. In the both groups, the serum TSH and anti-TPO antibody levels were measured and assessed before and after the intervention.

Results: After the interventions, the mean serum TSH reduction in the intervention and placebo groups was -10.98 ± 33.31 and -3.20 ± 38.36, respectively, which were not statistically significant. However, the mean serum anti-TPO Ab concentration increased in the intervention and placebo groups (109.81 ± 51.49% vs. 173.17 ± 96.26%), between which the difference was not statistically significant ( >0.05) despite a slight increase in the mean anti-TPO level in the intervention group.

Conclusion: The results of the current study indicated that selenium supplementation has no significant effect on serum anti-TPO Ab and TSH levels in the patients with subclinical hypothyroidism. Studies with larger sample size and with different doses of selenium are needed to reach more precise results.

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References

Toulis K, Anastasilakis A, Tzellos T, Goulis D, Kouvelas D . Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis. Thyroid. 2010; 20(10):1163-73. DOI: 10.1089/thy.2009.0351. View

Andrade G, Gorgulho B, Lotufo P, Bensenor I, Marchioni D . Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study. Nutrients. 2018; 10(6). PMC: 6024881. DOI: 10.3390/nu10060693. View

KIDDER G, MONTGOMERY C . Oxygenation of frog gastric mucosa in vitro. Am J Physiol. 1975; 229(6):1510-3. DOI: 10.1152/ajplegacy.1975.229.6.1510. View

Esposito D, Rotondi M, Accardo G, Vallone G, Conzo G, Docimo G . Influence of short-term selenium supplementation on the natural course of Hashimoto's thyroiditis: clinical results of a blinded placebo-controlled randomized prospective trial. J Endocrinol Invest. 2016; 40(1):83-89. DOI: 10.1007/s40618-016-0535-4. View

Karanikas G, Schuetz M, Kontur S, Duan H, Kommata S, Schoen R . No immunological benefit of selenium in consecutive patients with autoimmune thyroiditis. Thyroid. 2008; 18(1):7-12. DOI: 10.1089/thy.2007.0127. View

Tan L, Sang Z, Shen J, Wu Y, Yao Z, Zhang J . Selenium supplementation alleviates autoimmune thyroiditis by regulating expression of TH1/TH2 cytokines. Biomed Environ Sci. 2013; 26(11):920-5. DOI: 10.3967/bes2013.022. View

Duntas L, Mantzou E, Koutras D . Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis. Eur J Endocrinol. 2003; 148(4):389-93. DOI: 10.1530/eje.0.1480389. View

Hegedus L, Bonnema S, Winther K . Selenium in the Treatment of Thyroid Diseases: An Element in Search of the Relevant Indications?. Eur Thyroid J. 2016; 5(3):149-151. PMC: 5091242. DOI: 10.1159/000448002. View

Pilli T, Cantara S, Schomburg L, Cenci V, Cardinale S, Heid E . IFNγ-Inducible Chemokines Decrease upon Selenomethionine Supplementation in Women with Euthyroid Autoimmune Thyroiditis: Comparison between Two Doses of Selenomethionine (80 or 160 μg) versus Placebo. Eur Thyroid J. 2016; 4(4):226-33. PMC: 4716423. DOI: 10.1159/000439589. View

10.

Wojciechowska-Durczynska K, Lewinski A . Search for relevant indications for selenium supplementation in thyroid diseases. Neuro Endocrinol Lett. 2017; 38(4):237-241. View

11.

Stuss M, Michalska-Kasiczak M, Sewerynek E . The role of selenium in thyroid gland pathophysiology. Endokrynol Pol. 2017; 68(4):440-465. DOI: 10.5603/EP.2017.0051. View

12.

Winther K, Wichman J, Bonnema S, Hegedus L . Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis. Endocrine. 2016; 55(2):376-385. PMC: 5272877. DOI: 10.1007/s12020-016-1098-z. View

13.

Ventura M, Melo M, Carrilho F . Selenium and Thyroid Disease: From Pathophysiology to Treatment. Int J Endocrinol. 2017; 2017:1297658. PMC: 5307254. DOI: 10.1155/2017/1297658. View

14.

Kohrle J . Selenium and the thyroid. Curr Opin Endocrinol Diabetes Obes. 2015; 22(5):392-401. DOI: 10.1097/MED.0000000000000190. View

15.

Winther K, Papini E, Attanasio R, Negro R, Hegedus L . A 2018 European Thyroid Association Survey on the Use of Selenium Supplementation in Hashimoto's Thyroiditis. Eur Thyroid J. 2020; 9(2):99-105. PMC: 7109430. DOI: 10.1159/000504781. View

16.

Mahmoodianfard S, Vafa M, Golgiri F, Khoshniat M, Gohari M, Solati Z . Effects of Zinc and Selenium Supplementation on Thyroid Function in Overweight and Obese Hypothyroid Female Patients: A Randomized Double-Blind Controlled Trial. J Am Coll Nutr. 2015; 34(5):391-9. DOI: 10.1080/07315724.2014.926161. View

17.

Santos L, Neves C, Melo M, Soares P . Selenium and Selenoproteins in Immune Mediated Thyroid Disorders. Diagnostics (Basel). 2018; 8(4). PMC: 6316875. DOI: 10.3390/diagnostics8040070. View

18.

Kachouei A, Rezvanian H, Amini M, Aminorroaya A, Moradi E . The Effect of Levothyroxine and Selenium versus Levothyroxine Alone on Reducing the Level of Anti-thyroid Peroxidase Antibody in Autoimmune Hypothyroid Patients. Adv Biomed Res. 2018; 7:1. PMC: 5812089. DOI: 10.4103/2277-9175.223735. View

19.

Ott J, Promberger R, Kober F, Neuhold N, Tea M, Huber J . Hashimoto's thyroiditis affects symptom load and quality of life unrelated to hypothyroidism: a prospective case-control study in women undergoing thyroidectomy for benign goiter. Thyroid. 2010; 21(2):161-7. DOI: 10.1089/thy.2010.0191. View

20.

Caturegli P, De Remigis A, Rose N . Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev. 2014; 13(4-5):391-7. DOI: 10.1016/j.autrev.2014.01.007. View