Pharmacological Basis for the Potential Role of Azithromycin and Doxycycline in Management of COVID-19

Overview

Journal Arab J Chem

Date 2021 Dec 15

PMID 34909062

Citations 6

Authors

Ahmed S Ali

Mai A ASattar

Shahid Karim

Dina Kutbi

Hanin Aljohani

Duaa Bakhshwin

Mohammed Alsieni

Huda M AlKreathy

Affiliations

Soon will be listed here.

Abstract

A novel corona virus SARS-CoV-2 has led to an outbreak of the highly infectious pandemic COVID-19 complicated viral pneumonia. Patients with risk factors frequently develop secondary infections where the role of appropriate antibiotics is mandatory. However, the efforts of drug repurposing lead to recognizing the role of certain antibiotics beyond the management of infection. The current review provided the detailed antiviral, immunomodulatory effect, unique pharmacokinetic profile of two antibiotics namely azithromycin (AZ) and doxycycline (DOX). It summarizes current clinical trials and concerns regarding safety issues of these drugs. Azithromycin (AZ) has amazing lung tissue access, wide range antibacterial efficacy, conceivable antiviral action against COVID-19. It also showed efficacy when combined with other antiviral drugs in limited clinical trials, but many clinicians raise concerns regarding cardiovascular risk in susceptible patients. DOX has a considerable role in the management of pneumonia, it has some advantages including cardiac safety, very good access to lung tissue, potential antiviral, and immunomodulation impact by several mechanisms. The pharmacological profiles of both drugs are heightening considering these medications for further studies in the management of COVID-19.

Citing Articles

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