Genome Analysis Provides Insight into Hyper-virulence of Streptococcus Suis LSM178, a Human Strain with a Novel Sequence Type 1005

Overview

Journal Sci Rep

Specialty Science

Date 2021 Dec 15

PMID 34907269

Citations 2

Authors

Yong Hu

Shiming Fu

Geng Zou

Anusak Kerdsin

Xiabing Chen

Xingxing Dong

Lin Teng

Jinquan Li

Affiliations

Soon will be listed here.

Abstract

Streptococcus suis has been well-recognized as a zoonotic pathogen worldwide, and the diversity and unpredictable adaptive potential of sporadic human strains represent a great risk to the public health. In this study, S. suis LSM178, isolated from a patient in contact with pigs and raw pork, was assessed as a hyper-virulent strain and interpreted for the virulence based on its genetic information. The strain was more invasive for Caco-2 cells than two other S. suis strains, SC19 and P1/7. Sequence analysis designated LSM178 with serotype 2 and a novel sequence type 1005. Phylogenetic analysis showed that LSM178 clustered with highly virulent strains including all human strains and epidemic strains. Compared with other strains, these S. suis have the most and the same virulent factors and a type I-89 K pathogenicity island. Further, groups of genes were identified to distinguish these highly virulent strains from other generally virulent strains, emphasizing the key roles of genes modeling transcription, cell barrier, replication, recombination and repair on virulence regulation. Additionally, LSM178 contains a novel prophage conducive potentially to pathogenicity.

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