Effect of Electro-acupuncture on Ovarian Function of Women with Diminished Ovarian Reserve: Study Protocol for a Randomized Controlled Trial

Overview

Journal Trials

Publisher Biomed Central

Specialties General Medicine
Pharmacology

Date 2021 Dec 15

PMID 34906206

Citations 3

Authors

Le Yang

Hanwang Zhang

Li Zhou

Ying Gao

Lijuan Yang

Yajun Hu

Lu Xu

Dongmei Huang

Affiliations

Soon will be listed here.

Abstract

Background: Diminished ovarian reserve (DOR) is the precursor state of ovarian failure and can cause the decline of women's reproductive function. DOR also leads to poor outcome of in vitro fertilization and embryo transfer (IVF-ET) by affecting the oocytes, high qualified embryo rate, pregnancy rate, etc. Some studies have demonstrated that acupuncture can improve ovarian function. But to date, there is limited evidence indicating that acupuncture or electro-acupuncture is efficient to DOR. This trial aims to evaluate the efficiency and safety of electro-acupuncture for the ovarian function and the following outcome of IVF-ET in DOR patients.

Methods: This will be a multicenter randomized controlled clinical trial. A total of more than 338 women with DOR will be randomly allocated to treatment and control groups in 1:1 ratio receiving acupuncture before undergoing IVF-ET. The primary outcome will be the clinical pregnancy rate per cycle of IVF-ET after acupuncture. The secondary outcomes will be ovarian reserve function, outcomes of IVT-ET, blood biochemical index, Massachusetts General Hospital Acupuncture Sensation Scale (MASS), scores from the self-rating anxiety and depression scale, quality of life, and pregnancy outcomes. The safety of acupuncture will also be assessed.

Discussion: The results of this trial may provide high-quality evidence regarding the effectiveness of electro-acupuncture in the treatment of DOR and following outcomes of IVF-ET. This will also help patients with DOR and their physicians by offering a new treatment option.

Trial Registration: Chinese Clinical Trial Registry ChiCTR1900024626 . Registered on 19 July 2019.

Citing Articles

The correlation of acupuncture and moxibustion points for the treatment of diminished ovarian reserve and premature ovarian failure: A systematic review based on complex network.

Yang Z, Zhu Z, Yang X, Zhang W, Chen P, Jin L Medicine (Baltimore). 2024; 103(44):e40185.

PMID: 39496037 PMC: 11537596. DOI: 10.1097/MD.0000000000040185.

Conception vessel acupuncture research regularity in the treatment of diminished ovarian reserve: a multi-center, large-sample prospective cohort study protocol.

Zhang X, Sun H, Zhang N, Mou Z, Xia Q, Du D Front Endocrinol (Lausanne). 2024; 15:1380444.

PMID: 39286277 PMC: 11402716. DOI: 10.3389/fendo.2024.1380444.

Evaluation of Serum AMH, INHB Combined with Basic FSH on Ovarian Reserve Function after Laparoscopic Ovarian Endometriosis Cystectomy.

Tang Y, Li Y Front Surg. 2022; 9:906020.

PMID: 35662819 PMC: 9158433. DOI: 10.3389/fsurg.2022.906020.

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