Biological Activities and the Essential Oil Analysis of and

Overview

Journal Iran J Pharm Res

Publisher Brieflands

Specialty Pharmacology

Date 2021 Dec 14

PMID 34903977

Citations 1

Authors

Ebrahim Salimi-Sabour

Farshad H Shirazi

Arash Mahboubi

Faraz Mojab

Mahboubeh Irani

Affiliations

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Abstract

This research aimed to evaluate the cytotoxicity, anti-bacterial, anti-fungal and heme polymerization inhibition activities, as well as the detection of the chemical composition of essential oils and measurement of the amount of total phenol and flavonoids of and . growth inhibitory effects of methanol extracts on A2780, T-47D, A549 and Hep-G2 cells were evaluated by MTT assay. MIC and MBC/MFC were determined by the agar dilution method. The anti-malarial activity of herbs was assessed with an inhibition test of heme detoxification (ITHD). Total phenol and flavonoids content measured by Folin-Ciocalteu method. The essential oils from two herbs were extracted by hydro-distillation, and GC/MS analyzed their compositions. Cell studies against selected cell lines growth in MTT assay were related to on Hep-G2 with IC of 4.521 µg/mL. The MIC of anti-bacterial and anti-fungal effects is related to extract on and with 15.62 and 62.5 mg/mL, respectively. Both extracts do not have anti-malarial activity. content was richer in total phenol and flavonoids rather than the other herb. -benzyl benzyl alcohol (46.7%) and butyl phthalate (14.7%) are the major compounds of ; main components of are 3-methyl-tetrahydrofuran (24.6%) and oleic acid (15.4%). In conclusion, with more phenol and flavonoids content showed better results in terms of biological activities.

Citing Articles

Analysis of essential oil composition and assessing the antibacterial and antioxidant properties of the ethanol extract.

Talebi M, Oskouie A, Mahboubi A, Khani M, Mojab F Heliyon. 2024; 10(21):e38389.

PMID: 39568859 PMC: 11577149. DOI: 10.1016/j.heliyon.2024.e38389.

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