Wrist Circumference As a Novel Predictor of Transition from Metabolically Healthy to Unhealthy Phenotype in Overweight/obese Adults: a Gender-stratified 15.5-year Follow-up

Overview

Journal BMC Public Health

Publisher Biomed Central

Specialty Public Health

Date 2021 Dec 14

PMID 34903195

Citations 3

Authors

Pouria Mousapour

Maryam Barzin

Majid Valizadeh

Maryam Mahdavi

Farzad Hadaegh

Fereidoun Azizi

Farhad Hosseinpanah

Affiliations

Soon will be listed here.

Abstract

Background: Individuals with transition from metabolically healthy overweight/obese (MHO) to metabolically unhealthy overweight/obese (MUO) phenotype are significantly predisposed to greater risks of cardiovascular events compared to those with a persistent MHO phenotype. The aim of this study was to evaluate the predictive performance of wrist circumference for this transition in adults over a 15.5-year follow-up.

Methods: We included 309 males and 821 females with the age of ≥18 years old, body mass index ≥25 kg/m, and metabolically healthy status according to the criteria of the Joint Interim Statement. The incidence of MUO phenotype was evaluated for each gender, across tertiles wrist circumference, using Cox-proportional hazard models.

Results: The overall rate of transition from MHO to MUO phenotype was 87.1% in males and 77.5% in females. The hazard ratios (HRs) with 95% CI across second and third tertiles of wrist circumference were 0.89 (0.64-1.24) and 1.31 (0.99-1.73) in men (P for trend =0.027); and 1.34 (1.09-1.66) and 1.61 (1.30-2.00) in women (P for trend <0.001), respectively. After multivariable adjustment, HRs across second and third tertiles of wrist circumference were 0.92 (0.64-1.32) and 1.18 (0.83-1.67) in males (p for trend =0.352), and 1.32 (1.05-1.65) and 1.34 (1.06-1.96) in females (p for trend =0.025), respectively.

Conclusions: Wrist circumference significantly predicts the transition from MHO to MUO phenotype in adults of both genders. However, it is an independent predictor of the transition only in females. Future studies are warranted to clarify the role of wrist circumference mechanisms on metabolic risk deterioration.

Citing Articles

Wrist Circumference Cutoff Points for Determining Excess Weight Levels and Predicting Cardiometabolic Risk in Adults.

Pereira L, de Souza M, Aidar F, Getirana-Mota M, Dos Santos-Junior A, Filho M Int J Environ Res Public Health. 2024; 21(5).

PMID: 38791764 PMC: 11120788. DOI: 10.3390/ijerph21050549.

Plasma catestatin levels are related to metabolic parameters in patients with essential hypertension and type 2 diabetes mellitus.

Pankova O, Korzh O Heart Vessels. 2023; 39(2):144-159.

PMID: 37758851 DOI: 10.1007/s00380-023-02318-w.

The Pathological Links between Adiposity and the Carpal Tunnel Syndrome.

Otelea M, Nartea R, Popescu F, Covaleov A, Mitoiu B, Nica A Curr Issues Mol Biol. 2022; 44(6):2646-2663.

PMID: 35735622 PMC: 9221759. DOI: 10.3390/cimb44060181.

References

Povel C, Boer J, Reiling E, Feskens E . Genetic variants and the metabolic syndrome: a systematic review. Obes Rev. 2011; 12(11):952-67. DOI: 10.1111/j.1467-789X.2011.00907.x. View

Mohebi R, Mohebi A, Sheikholeslami F, Azizi F, Hadaegh F . Wrist circumference as a novel predictor of hypertension and cardiovascular disease: results of a decade follow up in a West Asian cohort. J Am Soc Hypertens. 2014; 8(11):800-7. DOI: 10.1016/j.jash.2014.08.010. View

Jahangiri Noudeh Y, Hadaegh F, Vatankhah N, Momenan A, Saadat N, Khalili D . Wrist circumference as a novel predictor of diabetes and prediabetes: results of cross-sectional and 8.8-year follow-up studies. J Clin Endocrinol Metab. 2013; 98(2):777-84. DOI: 10.1210/jc.2012-2416. View

Lin H, Zhang L, Zheng R, Zheng Y . The prevalence, metabolic risk and effects of lifestyle intervention for metabolically healthy obesity: a systematic review and meta-analysis: A PRISMA-compliant article. Medicine (Baltimore). 2018; 96(47):e8838. PMC: 5708991. DOI: 10.1097/MD.0000000000008838. View

. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1659-1724. PMC: 5388856. DOI: 10.1016/S0140-6736(16)31679-8. View

Hwang Y, Hayashi T, Fujimoto W, Kahn S, Leonetti D, McNeely M . Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype. Int J Obes (Lond). 2015; 39(9):1365-70. PMC: 4564328. DOI: 10.1038/ijo.2015.75. View

Capizzi M, Leto G, Petrone A, Zampetti S, Papa R, Osimani M . Wrist circumference is a clinical marker of insulin resistance in overweight and obese children and adolescents. Circulation. 2011; 123(16):1757-62. DOI: 10.1161/CIRCULATIONAHA.110.012898. View

Luordi C, Maddaloni E, Bizzarri C, Pedicelli S, Zampetti S, DOnofrio L . Wrist circumference is a biomarker of adipose tissue dysfunction and cardiovascular risk in children with obesity. J Endocrinol Invest. 2019; 43(1):101-107. DOI: 10.1007/s40618-019-01086-7. View

Maddaloni E, Cavallari I, De Pascalis M, Keenan H, Park K, Manfrini S . Relation of Body Circumferences to Cardiometabolic Disease in Overweight-Obese Subjects. Am J Cardiol. 2016; 118(6):822-827. DOI: 10.1016/j.amjcard.2016.06.044. View

10.

Kajale N, Khadilkar A, Chiplonkar S, Khadilkar V . Body fat indices for identifying risk of hypertension in Indian children. Indian Pediatr. 2014; 51(7):555-60. DOI: 10.1007/s13312-014-0446-4. View

11.

Roberson L, Aneni E, Maziak W, Agatston A, Feldman T, Rouseff M . Beyond BMI: The "Metabolically healthy obese" phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality -- a systematic review. BMC Public Health. 2014; 14:14. PMC: 3890499. DOI: 10.1186/1471-2458-14-14. View

12.

Fukumoto S, Martin T . Bone as an endocrine organ. Trends Endocrinol Metab. 2009; 20(5):230-6. DOI: 10.1016/j.tem.2009.02.001. View

13.

Ferrara L, Capaldo B, Mancusi C, Lee E, Howard B, Devereux R . Cardiometabolic risk in overweight subjects with or without relative fat-free mass deficiency: the Strong Heart Study. Nutr Metab Cardiovasc Dis. 2013; 24(3):271-6. PMC: 3959567. DOI: 10.1016/j.numecd.2013.08.009. View

14.

Amisi C, Ciccozzi M, Pozzilli P . Wrist circumference: A new marker for insulin resistance in African women with polycystic ovary syndrome. World J Diabetes. 2020; 11(2):42-51. PMC: 6969708. DOI: 10.4239/wjd.v11.i2.42. View

15.

Kouvari M, Panagiotakos D, Yannakoulia M, Georgousopoulou E, Critselis E, Chrysohoou C . Transition from metabolically benign to metabolically unhealthy obesity and 10-year cardiovascular disease incidence: The ATTICA cohort study. Metabolism. 2019; 93:18-24. DOI: 10.1016/j.metabol.2019.01.003. View

16.

Kogelman L, Fu J, Franke L, Greve J, Hofker M, Rensen S . Inter-Tissue Gene Co-Expression Networks between Metabolically Healthy and Unhealthy Obese Individuals. PLoS One. 2016; 11(12):e0167519. PMC: 5132173. DOI: 10.1371/journal.pone.0167519. View

17.

Delavari A, Forouzanfar M, Alikhani S, Sharifian A, Kelishadi R . First nationwide study of the prevalence of the metabolic syndrome and optimal cutoff points of waist circumference in the Middle East: the national survey of risk factors for noncommunicable diseases of Iran. Diabetes Care. 2009; 32(6):1092-7. PMC: 2681035. DOI: 10.2337/dc08-1800. View

18.

Amini A, Soltanian N, Iraj B, Askari G, Ebneyamin S, Ghias M . Association of wrist circumference with cardio metabolic risk factors. J Pak Med Assoc. 2012; 62(3 Suppl 2):S34-6. View

19.

Huxley R, Mendis S, Zheleznyakov E, Reddy S, Chan J . Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk--a review of the literature. Eur J Clin Nutr. 2009; 64(1):16-22. DOI: 10.1038/ejcn.2009.68. View

20.

Kelishadi R, Qorbani M, Hosseini M, Bahreynian M, Djalalinia S, Motlagh M . Percentiles for anthropometric measures in Iranian children and adolescents: the CASPIAN-IV study. J Pediatr Endocrinol Metab. 2016; 29(9):1069-76. DOI: 10.1515/jpem-2016-0041. View