Traditional Chinese Medicine in Treating IgA Nephropathy: From Basic Science to Clinical Research

Overview

Journal J Transl Int Med

Publisher Sciendo

Specialty General Medicine

Date 2021 Dec 13

PMID 34900626

Citations 9

Authors

Xin-Hui Wang

Rui Lang

Ying Liang

Qin Zeng

Nan Chen

Ren-Huan Yu

Affiliations

Soon will be listed here.

Abstract

IgA nephropathy (IgAN) is a major cause of chronic kidney disease (CKD) and end-stage renal disease worldwide. Currently, clinical interventions for IgAN are limited, and many patients seek out alternative therapies such as traditional Chinese medicine (TCM). In the last several years, TCM has accumulated ample application experiences and achieved favorable clinical effects. This article summarizes high-quality research from basic science to clinical applications aimed to provide more evidence-based medicine proof for the clinical treatment of IgAN. In summary, qi and yin deficiency accounted for the largest proportion in IgAN patients, and the treatment of IgAN should be based on supplementing qi and nourishing yin. Further, for patients with severe IgAN, the treatment combination of Chinese and Western medicines is better than pure Chinese medicine or hormone therapy. In addition, the pharmacological mechanism of Chinese herbal medicines is mostly based on restoring the immune function, relieving the inflammation damage, and inhibiting proliferation of the glomerular mesangial cells.

Citing Articles

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Network Pharmacology and Experimental Validation to Explore That Celastrol Targeting PTEN is the Potential Mechanism of (Lév.) Hutch Against IgA Nephropathy.

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