Late Lung Metastasis in a Patient with a Clear Cell Chondrosarcoma: An Indication for a Life-Long Follow-Up?

Overview

Journal Case Rep Oncol Med

Publisher Wiley

Specialty Oncology

Date 2021 Dec 13

PMID 34900355

Authors

Paulien West

Celine Jacobs

Michael Saerens

David Creytens

Gwen Sys

Lore Lapeire

Affiliations

Soon will be listed here.

Abstract

Background: Clear cell chondrosarcoma (CCCS) is a rare subtype of chondrosarcoma and comprises between 1.6% and 2.5% of all chondrosarcoma. They are known to be chemo- and radiotherapy resistant; surgical resection is therefore the therapy of choice.

Methods: We present a 63-year-old woman with a progressive lung nodule 20 years after initial diagnosis and treatment of a clear cell chondrosarcoma of the right os naviculare.

Results: On serial CT scans of the chest, an asymptomatic, slowly growing nodule in the left upper lung lobe was detected. CT-guided transthoracic biopsy of this nodule confirmed the diagnosis of a chondrosarcoma lung metastasis. Video-assisted thoracoscopic wedge resection was performed with complete removal of the nodule. The patient recovered well from surgery and remains in good health during further follow-up.

Conclusion: Given the tendency of clear cell chondrosarcoma to recur and metastasize after extended periods of time, a long-term, possibly life-long follow-up and clinical surveillance is advisable in these patients.

References

Moura D, Fonseca R, Freitas J, Figueiredo A, Casanova J . Reconstruction with iliac pedestal cup and proximal femur tumor prosthesis after wide resection of chondrosarcoma - 10-year follow-up results. Rev Bras Ortop. 2017; 52(6):748-754. PMC: 5720845. DOI: 10.1016/j.rboe.2016.11.007. View

Komiya S, Inoue A, Nakashima M, Takagi H, Ikuta H, Irie K . Clear-cell chondrosarcoma--a case report suggesting a malignant variation of chondroblastoma. Kurume Med J. 1986; 33(3):131-7. DOI: 10.2739/kurumemedj.33.131. View

Itala A, Leerapun T, Inwards C, Collins M, Scully S . An institutional review of clear cell chondrosarcoma. Clin Orthop Relat Res. 2005; 440:209-12. DOI: 10.1097/01.blo.0000174686.70003.e0. View

Hsu W, McCarthy E, Ziya L Gokaslan , Wolinsky J . Clear-cell chondrosarcoma of the lumbar spine: case report and review of the literature. Neurosurgery. 2011; 68(4):E1160-4. DOI: 10.1227/NEU.0b013e31820ccf90. View

Lee S, Ahn G, Chi J, Ham E . Clear-cell chondrosarcoma--a case report. J Korean Med Sci. 1989; 4(3):155-8. PMC: 3053696. DOI: 10.3346/jkms.1989.4.3.155. View

Bagley L, Kneeland J, Dalinka M, Bullough P, Brooks J . Unusual behavior of clear cell chondrosarcoma. Skeletal Radiol. 1993; 22(4):279-82. DOI: 10.1007/BF00197674. View

Hartwright D, Mangham D, Grimer R . Reactivation of tumor after 19 years? A case of local recurrence in clear cell chondrosarcoma. Int Orthop. 2000; 24(2):112-4. PMC: 3620596. DOI: 10.1007/s002640000122. View

Ron I, Amir G, Inbar M, Chaitchik S . Clear cell chondrosarcoma of rib following repetitive low-impact trauma. Am J Clin Oncol. 1995; 18(1):87-9. DOI: 10.1097/00000421-199502000-00019. View

Klein A, Tauscher F, Birkenmaier C, Baur-Melnyk A, Knosel T, Jansson V . Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature. J Bone Oncol. 2019; 19:100267. PMC: 6879987. DOI: 10.1016/j.jbo.2019.100267. View

10.

Nagmani S, Rakesh J, Aditya A, Sandeep P, Arjun R, Debasis G . Clear cell chondrosarcoma calcaneum - a case report and review of literature. Foot (Edinb). 2015; 25(1):36-40. DOI: 10.1016/j.foot.2014.11.006. View

11.

Grimm N, Tainter D, Eward W, Brigman B . Tumors of the Epiphyses. JBJS Rev. 2017; 5(5):e4. DOI: 10.2106/JBJS.RVW.16.00080. View

12.

Caetano de Oliveira R, Reith J, Casanova J . Clear Cell Chondrosarcoma with Rib Cage Metastasis: Case Report. Case Rep Oncol. 2021; 14(1):239-243. PMC: 7983667. DOI: 10.1159/000512067. View

13.

Jiang X, Pantanowitz L, Bui M, Esther R, Budwit D, Dodd L . Clear cell chondrosarcoma: Cytologic findings in six cases. Diagn Cytopathol. 2013; 42(9):784-91. DOI: 10.1002/dc.23043. View

14.

Bjornsson J, Unni K, Dahlin D, Beabout J, Sim F . Clear cell chondrosarcoma of bone. Observations in 47 cases. Am J Surg Pathol. 1984; 8(3):223-30. DOI: 10.1097/00000478-198403000-00009. View

15.

Ayoub K, Grimer R, Carter S, Mangham D, Davies A, Tillman R . Clear cell chondrosarcoma of bone. Sarcoma. 2008; 3(2):115-9. PMC: 2395420. DOI: 10.1080/13577149977749. View

16.

Srikanth K, Kulkarni A, Davies A, Sumathi V, Grimer R . Clear cell chondrosarcoma in association with niemann-pick disease. Sarcoma. 2008; 9(1-2):33-6. PMC: 2395625. DOI: 10.1080/13577140500090030. View

17.

Casali P, Bielack S, Abecassis N, Aro H, Bauer S, Biagini R . Bone sarcomas: ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018; 29(Suppl 4):iv79-iv95. DOI: 10.1093/annonc/mdy310. View

18.

Elojeimy S, Ahrens W, Howard B, Patt J, Stone T, Kneisl J . Clear-cell chondrosarcoma of the humerus. Radiol Case Rep. 2016; 8(2):848. PMC: 4900123. DOI: 10.2484/rcr.v8i2.848. View

19.

Unni K, Dahlin D, Beabout J, Sim F . Chondrosarcoma: clear-cell variant. A report of sixteen cases. J Bone Joint Surg Am. 1976; 58(5):676-83. View

20.

Simsek A, Sipahioglu S, Ataoglu O, Cila E . Clear cell chondrosarcoma of the proximal femur with intrapelvic extension. Arch Orthop Trauma Surg. 2004; 125(1):66-9. DOI: 10.1007/s00402-004-0755-5. View